Acne: cientistas projetam “bactérias inteligentes” para tratar doença

[{"selector":"#anim-14c83883-d864-4fba-ac1f-cece2c6c58d8","keyframes":{"opacity":[0,1]},"delay":0,"duration":1000,"easing":"cubic-bezier(0.4, 0.4, 0.0, 1)","fill":"both"}] [{"selector":"#anim-23d6ffd9-a04a-4d2f-a074-ea415295f5cb","keyframes":{"opacity":[0,1]},"delay":0,"duration":500,"easing":"cubic-bezier(.3,0,.55,1)","fill":"both"}] [{"selector":"#anim-5aae4516-9504-41a0-a3d4-796122d69885","keyframes":{"transform":["scale(0.3333333333333333)","scale(1)"]},"delay":0,"duration":500,"easing":"cubic-bezier(.3,0,.55,1)","fill":"forwards"}] [{"selector":"#anim-60802bc9-dc14-4875-a36b-39114f6e3b47","keyframes":{"opacity":[0,1]},"delay":0,"duration":600,"easing":"cubic-bezier(0.4, 0.4, 0.0, 1)","fill":"both"}] Anna Nekrashevich/Pexels

[{"selector":"#anim-3f42ba69-f57b-4b9a-8882-5abc44c8ff9b","keyframes":{"opacity":[0,1]},"delay":0,"duration":1500,"easing":"cubic-bezier(0.4, 0.4, 0.0, 1)","fill":"both"}] [{"selector":"#anim-b30f5368-e9b9-43de-8082-84b0ff1b6ef4","keyframes":{"opacity":[0,1]},"delay":0,"duration":500,"easing":"cubic-bezier(.3,0,.55,1)","fill":"both"}] [{"selector":"#anim-58bed335-93b5-4c7d-8027-071afb59976d","keyframes":{"transform":["scale(0.3333333333333333)","scale(1)"]},"delay":0,"duration":500,"easing":"cubic-bezier(.3,0,.55,1)","fill":"forwards"}] [{"selector":"#anim-86474f90-7c43-4b5d-aaad-b9ef9ee5ced8","keyframes":{"opacity":[0,1]},"delay":0,"duration":600,"easing":"cubic-bezier(0.4, 0.4, 0.0, 1)","fill":"both"}] Um estudo experimental liderado pela Universidade Pompeu Fabra, de Barcelona, na Espanha, mostrou que um tipo de bactéria presente na pele pode produzir uma molécula que regula a oleosidade e ajudar a tratar sintomas de acne sem destruir o microbioma da pele Ron Lach/Pexels

[{"selector":"#anim-ceea88cd-5c29-4e31-afe0-0e2ca3927acb","keyframes":{"opacity":[0,1]},"delay":0,"duration":1500,"easing":"cubic-bezier(0.4, 0.4, 0.0, 1)","fill":"both"}] [{"selector":"#anim-acaf1cd7-eb01-4182-8aba-933e493fb564","keyframes":{"opacity":[0,1]},"delay":0,"duration":500,"easing":"cubic-bezier(.3,0,.55,1)","fill":"both"}] [{"selector":"#anim-eca77e54-954f-46f2-a094-4b6bbbee92b7","keyframes":{"transform":["scale(0.3333333333333333)","scale(1)"]},"delay":0,"duration":500,"easing":"cubic-bezier(.3,0,.55,1)","fill":"forwards"}] [{"selector":"#anim-7e513add-3ec4-44a9-8cfb-6f1e84359a14","keyframes":{"opacity":[0,1]},"delay":0,"duration":600,"easing":"cubic-bezier(0.4, 0.4, 0.0, 1)","fill":"both"}] Pesquisadores do Laboratório de Biologia Sintética Translacional do Departamento de Medicina e Ciências da Vida testaram a bactéria Cutibacterium acnes em linhagens de células da pele e em camundongos CDC/Bobby Strong

[{"selector":"#anim-3123cd6f-dd85-4816-a1e3-0b7fe7ad854b","keyframes":{"opacity":[0,1]},"delay":0,"duration":1500,"easing":"cubic-bezier(0.4, 0.4, 0.0, 1)","fill":"both"}] [{"selector":"#anim-c517246d-c4d1-4308-ade2-0be51615fbf7","keyframes":{"opacity":[0,1]},"delay":0,"duration":500,"easing":"cubic-bezier(.3,0,.55,1)","fill":"both"}] [{"selector":"#anim-436bf866-e7dc-4b65-914a-cfa1f79ba037","keyframes":{"transform":["scale(0.3333333333333333)","scale(1)"]},"delay":0,"duration":500,"easing":"cubic-bezier(.3,0,.55,1)","fill":"forwards"}] [{"selector":"#anim-2e866e12-3e9b-4456-8fda-e67b45cd8ccd","keyframes":{"opacity":[0,1]},"delay":0,"duration":600,"easing":"cubic-bezier(0.4, 0.4, 0.0, 1)","fill":"both"}] [{"selector":"#anim-958be3d1-160e-4a98-9e1a-e350f10cd968","keyframes":{"opacity":[0,1]},"delay":0,"duration":500,"easing":"cubic-bezier(.3,0,.55,1)","fill":"both"}] [{"selector":"#anim-8b734ab8-bf9e-473c-9018-3ee706379eb2","keyframes":{"transform":["scale(0.3333333333333333)","scale(1)"]},"delay":0,"duration":500,"easing":"cubic-bezier(.3,0,.55,1)","fill":"forwards"}] A proteína produzida foi a NGAL, mediadora da isotretinoína, medicamento usado para tratar a acne ao induzir a morte dos sebócitos Anna Nekrashevich/Pexels

[{"selector":"#anim-c135abcd-0100-4460-af5a-0e13a2fed5ed","keyframes":{"opacity":[0,1]},"delay":0,"duration":1500,"easing":"cubic-bezier(0.4, 0.4, 0.0, 1)","fill":"both"}] [{"selector":"#anim-63754a6d-a083-41d8-9870-889de27bbfd7","keyframes":{"opacity":[0,1]},"delay":0,"duration":500,"easing":"cubic-bezier(.3,0,.55,1)","fill":"both"}] [{"selector":"#anim-616ce0dc-c9d6-4181-8c5d-9aa1a3122c59","keyframes":{"transform":["scale(0.3333333333333333)","scale(1)"]},"delay":0,"duration":500,"easing":"cubic-bezier(.3,0,.55,1)","fill":"forwards"}] [{"selector":"#anim-6f0d61fa-fae3-4a93-9197-330b06ea9620","keyframes":{"opacity":[0,1]},"delay":0,"duration":600,"easing":"cubic-bezier(0.4, 0.4, 0.0, 1)","fill":"both"}] [{"selector":"#anim-c1c185ee-1c4f-47d4-92ee-b9ff5ea2944b","keyframes":{"opacity":[0,1]},"delay":0,"duration":500,"easing":"cubic-bezier(.3,0,.55,1)","fill":"both"}] [{"selector":"#anim-b685496e-b185-401f-809a-e6342fb12124","keyframes":{"transform":["scale(0.3333333333333333)","scale(1)"]},"delay":0,"duration":500,"easing":"cubic-bezier(.3,0,.55,1)","fill":"forwards"}] “Até agora, a C. acnes era considerada uma bactéria intratável. Foi incrivelmente difícil introduzir DNA e obter proteínas produzidas ou secretadas a partir de um elemento inserido em seu genoma”, explica Nastassia Knödlseder, principal autora do estudo Freepick

[{"selector":"#anim-430079ee-6c28-4f85-bd5a-9d53f44801e3","keyframes":{"opacity":[0,1]},"delay":0,"duration":1500,"easing":"cubic-bezier(0.4, 0.4, 0.0, 1)","fill":"both"}] [{"selector":"#anim-93b48990-a7ba-4f42-a191-58e52cc09455","keyframes":{"opacity":[0,1]},"delay":0,"duration":500,"easing":"cubic-bezier(.3,0,.55,1)","fill":"both"}] [{"selector":"#anim-53d83c4b-5427-4f71-aa88-d638f5245654","keyframes":{"transform":["scale(0.3333333333333333)","scale(1)"]},"delay":0,"duration":500,"easing":"cubic-bezier(.3,0,.55,1)","fill":"forwards"}] [{"selector":"#anim-7375ca41-e45a-4888-a1ab-e5629fa3eb0b","keyframes":{"opacity":[0,1]},"delay":0,"duration":600,"easing":"cubic-bezier(0.4, 0.4, 0.0, 1)","fill":"both"}] [{"selector":"#anim-5342513c-ebe2-4c83-9008-28e4dce0c6e0","keyframes":{"opacity":[0,1]},"delay":0,"duration":500,"easing":"cubic-bezier(.3,0,.55,1)","fill":"both"}] [{"selector":"#anim-79c13b0e-8ea0-41c6-8a23-f6fc7a8260a9","keyframes":{"transform":["scale(0.3333333333333333)","scale(1)"]},"delay":0,"duration":500,"easing":"cubic-bezier(.3,0,.55,1)","fill":"forwards"}] A descoberta, publicada na revista Nature Biotechnology, abre caminhos para que outros cientistas pesquisem a ação de bactérias na cura de doenças e outros tipos de “terapias vivas” Freepick

[{"selector":"#anim-d4296175-947f-4c4b-bb65-bc8c346b3ca4","keyframes":{"opacity":[0,1]},"delay":0,"duration":1500,"easing":"cubic-bezier(0.4, 0.4, 0.0, 1)","fill":"both"}] [{"selector":"#anim-e76510be-fb36-46ac-af8b-6dbe17429038","keyframes":{"opacity":[0,1]},"delay":0,"duration":500,"easing":"cubic-bezier(.3,0,.55,1)","fill":"both"}] [{"selector":"#anim-4675a23b-7e6c-4a5c-888a-04fc67f0ed5b","keyframes":{"transform":["scale(0.3333333333333333)","scale(1)"]},"delay":0,"duration":500,"easing":"cubic-bezier(.3,0,.55,1)","fill":"forwards"}] [{"selector":"#anim-650ed8b5-eed6-442d-88d0-70f4b580ad83","keyframes":{"opacity":[0,1]},"delay":0,"duration":600,"easing":"cubic-bezier(0.4, 0.4, 0.0, 1)","fill":"both"}] [{"selector":"#anim-15a1e9cf-9d36-49d7-8808-d7299bf19855","keyframes":{"opacity":[0,1]},"delay":0,"duration":500,"easing":"cubic-bezier(.3,0,.55,1)","fill":"both"}] [{"selector":"#anim-964fb19d-3b8e-4ced-8c0c-59f23ea3cbc1","keyframes":{"transform":["scale(0.3333333333333333)","scale(1)"]},"delay":0,"duration":500,"easing":"cubic-bezier(.3,0,.55,1)","fill":"forwards"}] “Desenvolvemos uma terapia tópica com abordagem direcionada, utilizando o que a natureza já possui. Projetamos uma bactéria que vive na pele e a faz produzir o que nossa pele precisa. Aqui focamos no tratamento da acne, mas essa plataforma pode ser estendida a diversas outras indicações”, Knödlseder Freepick

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[{"selector":"#anim-0a8c0cf1-ac50-4255-af31-ca9425961d8b","keyframes":{"opacity":[0,1]},"delay":0,"duration":600,"easing":"cubic-bezier(0.4, 0.4, 0.0, 1)","fill":"both"}] [{"selector":"#anim-d0e13dc8-b8c8-4339-bf19-ef8e75b9106e","keyframes":{"opacity":[0,1]},"delay":0,"duration":600,"easing":"cubic-bezier(0.4, 0.4, 0.0, 1)","fill":"both"}] [{"selector":"#anim-23282e3b-86cc-4f3c-bae7-345676a601dc","keyframes":{"opacity":[0,1]},"delay":0,"duration":1000,"easing":"cubic-bezier(0.2, 0.6, 0.0, 1)","fill":"both"}] [{"selector":"#anim-456abe4d-1402-42f4-8b3c-3cc167f1a08d","keyframes":{"transform":["translate3d(0px, 2132.63615%, 0)","translate3d(0px, 0px, 0)"]},"delay":0,"duration":1000,"easing":"cubic-bezier(0.2, 0.6, 0.0, 1)","fill":"both"}] [{"selector":"#anim-3252fef4-85bc-4dff-847b-fe0ceec7d61f","keyframes":{"opacity":[0,1]},"delay":0,"duration":600,"easing":"cubic-bezier(0.2, 0.6, 0.0, 1)","fill":"both"}] [{"selector":"#anim-21b3b629-dc71-4e3b-8bca-90f39c5e36e7","keyframes":{"transform":["translate3d(-117.84387%, 0px, 0)","translate3d(0px, 0px, 0)"]},"delay":0,"duration":600,"easing":"cubic-bezier(0.2, 0.6, 0.0, 1)","fill":"both"}] [{"selector":"#anim-8c22676b-5664-402a-9250-3a95161c526c","keyframes":{"opacity":[0,1]},"delay":0,"duration":1000,"easing":"cubic-bezier(0.2, 0.6, 0.0, 1)","fill":"both"}] [{"selector":"#anim-589edfb7-76cb-4bc4-af3f-082a7a5b4ce4","keyframes":{"transform":["translate3d(0px, 867.28444%, 0)","translate3d(0px, 0px, 0)"]},"delay":0,"duration":1000,"easing":"cubic-bezier(0.2, 0.6, 0.0, 1)","fill":"both"}] Freepick leia mais em