Vacina contra câncer com imunoterapia pode reduzir tumor no fígado

[{"selector":"#anim-077cf55e-9dea-4820-bc5b-210cbf582e95","keyframes":{"opacity":[0,1]},"delay":0,"duration":1000,"easing":"cubic-bezier(0.4, 0.4, 0.0, 1)","fill":"both"}] [{"selector":"#anim-28061c81-2f67-49fa-844e-158d4cd40dec","keyframes":{"opacity":[0,1]},"delay":0,"duration":500,"easing":"cubic-bezier(.3,0,.55,1)","fill":"both"}] [{"selector":"#anim-f20d0b35-44d8-4a54-b7e6-fd0f83db4e65","keyframes":{"transform":["scale(0.3333333333333333)","scale(1)"]},"delay":0,"duration":500,"easing":"cubic-bezier(.3,0,.55,1)","fill":"forwards"}] [{"selector":"#anim-fcbadc79-a827-46ba-8208-8353823a9214","keyframes":{"opacity":[0,1]},"delay":0,"duration":600,"easing":"cubic-bezier(0.4, 0.4, 0.0, 1)","fill":"both"}] FRANK MERIÑO/Pexels

[{"selector":"#anim-d6f64da1-1ddb-43df-908b-6bce374c7f25","keyframes":{"opacity":[0,1]},"delay":0,"duration":1500,"easing":"cubic-bezier(0.4, 0.4, 0.0, 1)","fill":"both"}] [{"selector":"#anim-711495b9-af64-47f9-9294-378057c1c34d","keyframes":{"opacity":[0,1]},"delay":0,"duration":500,"easing":"cubic-bezier(.3,0,.55,1)","fill":"both"}] [{"selector":"#anim-9c014e2d-bb12-406c-86a0-50660b3a25a0","keyframes":{"transform":["scale(0.3333333333333333)","scale(1)"]},"delay":0,"duration":500,"easing":"cubic-bezier(.3,0,.55,1)","fill":"forwards"}] [{"selector":"#anim-c7635c5f-021b-47cf-a4e9-fbc2ee29884c","keyframes":{"opacity":[0,1]},"delay":0,"duration":600,"easing":"cubic-bezier(0.4, 0.4, 0.0, 1)","fill":"both"}] Quase um terço dos pacientes com câncer de fígado avançado que receberam uma vacina personalizada desenvolvida pela Geneos Therapeutics junto com um medicamento de imunoterapia em um pequeno e inicial teste clínico viu seus tumores reduzirem Nataliya Vaitkevich/Pexels

[{"selector":"#anim-1e93a708-f123-4b31-ad3f-6afa16a8a837","keyframes":{"opacity":[0,1]},"delay":0,"duration":1500,"easing":"cubic-bezier(0.4, 0.4, 0.0, 1)","fill":"both"}] [{"selector":"#anim-59383ff7-3f71-48ca-bba6-af1f8fe9df8d","keyframes":{"opacity":[0,1]},"delay":0,"duration":500,"easing":"cubic-bezier(.3,0,.55,1)","fill":"both"}] [{"selector":"#anim-4b739315-62e7-4699-a9df-fcda750229f0","keyframes":{"transform":["scale(0.3333333333333333)","scale(1)"]},"delay":0,"duration":500,"easing":"cubic-bezier(.3,0,.55,1)","fill":"forwards"}] [{"selector":"#anim-0c394eb9-2c9a-4c7f-b1bd-ca6fa362910a","keyframes":{"opacity":[0,1]},"delay":0,"duration":600,"easing":"cubic-bezier(0.4, 0.4, 0.0, 1)","fill":"both"}] [{"selector":"#anim-9a20cd9a-ce3f-4d0a-80db-e77dba0aed84","keyframes":{"opacity":[0,1]},"delay":0,"duration":500,"easing":"cubic-bezier(.3,0,.55,1)","fill":"both"}] [{"selector":"#anim-6fd509fa-e75c-4db5-b81d-674b1af37e7e","keyframes":{"transform":["scale(0.3333333333333333)","scale(1)"]},"delay":0,"duration":500,"easing":"cubic-bezier(.3,0,.55,1)","fill":"forwards"}] O resultado foi aproximadamente o dobro da resposta geralmente vista apenas com a imunoterapia, segundo os pesquisadores cottonbro studio/Pexels

[{"selector":"#anim-7708a7ea-f036-49ee-8369-90d66cfaa9a5","keyframes":{"opacity":[0,1]},"delay":0,"duration":1500,"easing":"cubic-bezier(0.4, 0.4, 0.0, 1)","fill":"both"}] [{"selector":"#anim-eec61304-ebf8-430f-b9e7-c084c6410fb1","keyframes":{"opacity":[0,1]},"delay":0,"duration":500,"easing":"cubic-bezier(.3,0,.55,1)","fill":"both"}] [{"selector":"#anim-d057634e-4f1f-43d6-ae50-38f33d6cd107","keyframes":{"transform":["scale(0.3333333333333333)","scale(1)"]},"delay":0,"duration":500,"easing":"cubic-bezier(.3,0,.55,1)","fill":"forwards"}] [{"selector":"#anim-331479fc-0bc9-4972-a9b7-d8e516b8e425","keyframes":{"opacity":[0,1]},"delay":0,"duration":600,"easing":"cubic-bezier(0.4, 0.4, 0.0, 1)","fill":"both"}] [{"selector":"#anim-46176c4e-6237-488a-8d08-947306d88a2d","keyframes":{"opacity":[0,1]},"delay":0,"duration":500,"easing":"cubic-bezier(.3,0,.55,1)","fill":"both"}] [{"selector":"#anim-345d33d6-9db8-4b08-8307-10ff14b2bb0b","keyframes":{"transform":["scale(0.3333333333333333)","scale(1)"]},"delay":0,"duration":500,"easing":"cubic-bezier(.3,0,.55,1)","fill":"forwards"}] Resultados do estudo preliminar, publicados na revista Nature Medicine , sugerem que vacinas baseadas em mutações presentes apenas no tumor de um paciente podem impulsionar a capacidade do sistema imunológico de reconhecer e atacar cânceres difíceis de tratar SHVETS production/Pexels

[{"selector":"#anim-d030c920-1b57-4835-b6a8-006e913ff531","keyframes":{"opacity":[0,1]},"delay":0,"duration":1500,"easing":"cubic-bezier(0.4, 0.4, 0.0, 1)","fill":"both"}] [{"selector":"#anim-d023e6a1-5ce6-44b0-b94d-367eeb1cedb7","keyframes":{"opacity":[0,1]},"delay":0,"duration":500,"easing":"cubic-bezier(.3,0,.55,1)","fill":"both"}] [{"selector":"#anim-f56b325a-50fa-4741-a33b-7ebf5bc34a88","keyframes":{"transform":["scale(0.3333333333333333)","scale(1)"]},"delay":0,"duration":500,"easing":"cubic-bezier(.3,0,.55,1)","fill":"forwards"}] [{"selector":"#anim-1a510996-de41-40f0-90c1-afdc6d345666","keyframes":{"opacity":[0,1]},"delay":0,"duration":600,"easing":"cubic-bezier(0.4, 0.4, 0.0, 1)","fill":"both"}] [{"selector":"#anim-3882415b-3f0f-422f-b1da-3a092cfb987f","keyframes":{"opacity":[0,1]},"delay":0,"duration":500,"easing":"cubic-bezier(.3,0,.55,1)","fill":"both"}] [{"selector":"#anim-b6b3deee-3f97-41d8-bb1c-c792208b71d0","keyframes":{"transform":["scale(0.3333333333333333)","scale(1)"]},"delay":0,"duration":500,"easing":"cubic-bezier(.3,0,.55,1)","fill":"forwards"}] As descobertas, que precisam ser confirmadas em um estudo maior, aproximam ainda mais a indústria de vacinas contra o câncer eficazes, após muitos fracassos passados, e podem expandir os tipos de cânceres que essas terapias podem tratar Karolina Grabowska/Pexels

[{"selector":"#anim-56cd2660-be0f-4388-b212-483c23d480fa","keyframes":{"opacity":[0,1]},"delay":0,"duration":1500,"easing":"cubic-bezier(0.4, 0.4, 0.0, 1)","fill":"both"}] [{"selector":"#anim-a9532ef5-9168-4a4d-a4a9-4265bd685fd0","keyframes":{"opacity":[0,1]},"delay":0,"duration":500,"easing":"cubic-bezier(.3,0,.55,1)","fill":"both"}] [{"selector":"#anim-46b86a46-155d-448a-ab22-c1506489d708","keyframes":{"transform":["scale(0.3333333333333333)","scale(1)"]},"delay":0,"duration":500,"easing":"cubic-bezier(.3,0,.55,1)","fill":"forwards"}] [{"selector":"#anim-5a13ff42-db42-48c7-b53b-0b471f909fc6","keyframes":{"opacity":[0,1]},"delay":0,"duration":600,"easing":"cubic-bezier(0.4, 0.4, 0.0, 1)","fill":"both"}] [{"selector":"#anim-3d726872-ff37-46c6-9e9d-c37189b8d0f8","keyframes":{"opacity":[0,1]},"delay":0,"duration":500,"easing":"cubic-bezier(.3,0,.55,1)","fill":"both"}] [{"selector":"#anim-bbbf4512-3cf7-4997-9025-30a7e802a963","keyframes":{"transform":["scale(0.3333333333333333)","scale(1)"]},"delay":0,"duration":500,"easing":"cubic-bezier(.3,0,.55,1)","fill":"forwards"}] Para o estudo, os pesquisadores usaram amostras dos tumores dos pacientes para construir vacinas baseadas em neoantígenos — novas mutações presentes apenas no tumor de um paciente individual Polina Tankilevitch/Pexels

[{"selector":"#anim-788f52bb-76ef-4248-8bf3-66f33119b1e3","keyframes":{"opacity":[0,1]},"delay":0,"duration":1500,"easing":"cubic-bezier(0.4, 0.4, 0.0, 1)","fill":"both"}] [{"selector":"#anim-9e0d22c6-eee4-45d7-9eca-c9d817e01710","keyframes":{"opacity":[0,1]},"delay":0,"duration":500,"easing":"cubic-bezier(.3,0,.55,1)","fill":"both"}] [{"selector":"#anim-a192c3fd-a4c0-4527-a1e9-d7a1052699a5","keyframes":{"transform":["scale(0.3333333333333333)","scale(1)"]},"delay":0,"duration":500,"easing":"cubic-bezier(.3,0,.55,1)","fill":"forwards"}] [{"selector":"#anim-6cabe1ea-248c-4702-9c25-c8e5e57092d9","keyframes":{"opacity":[0,1]},"delay":0,"duration":600,"easing":"cubic-bezier(0.4, 0.4, 0.0, 1)","fill":"both"}] [{"selector":"#anim-048306b2-556d-49e5-9929-99f827dd762b","keyframes":{"opacity":[0,1]},"delay":0,"duration":500,"easing":"cubic-bezier(.3,0,.55,1)","fill":"both"}] [{"selector":"#anim-1a1a951e-a439-41f6-b1a2-916977bae38b","keyframes":{"transform":["scale(0.3333333333333333)","scale(1)"]},"delay":0,"duration":500,"easing":"cubic-bezier(.3,0,.55,1)","fill":"forwards"}] “Essa vacina essencialmente educa o sistema imunológico para reconhecer antígenos que ele ignorou”, diz o líder do estudo, Mark Yarchoan, do Centro de Câncer Kimmel da Johns Hopkins Thirdman/Pexels

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[{"selector":"#anim-691b6153-591d-4a57-9437-8c1971a05306","keyframes":{"opacity":[0,1]},"delay":0,"duration":600,"easing":"cubic-bezier(0.4, 0.4, 0.0, 1)","fill":"both"}] [{"selector":"#anim-119f6a0c-7f1c-4055-822f-fd43f48e183d","keyframes":{"opacity":[0,1]},"delay":0,"duration":600,"easing":"cubic-bezier(0.4, 0.4, 0.0, 1)","fill":"both"}] [{"selector":"#anim-3e8209a9-6f73-4a49-af3d-e9be1b216b24","keyframes":{"opacity":[0,1]},"delay":0,"duration":1000,"easing":"cubic-bezier(0.2, 0.6, 0.0, 1)","fill":"both"}] [{"selector":"#anim-d70ff590-4c53-4ace-90af-e177f88ef4dd","keyframes":{"transform":["translate3d(0px, 2132.63615%, 0)","translate3d(0px, 0px, 0)"]},"delay":0,"duration":1000,"easing":"cubic-bezier(0.2, 0.6, 0.0, 1)","fill":"both"}] [{"selector":"#anim-bed0be51-e332-41ad-9108-164d18f4aaaf","keyframes":{"opacity":[0,1]},"delay":0,"duration":600,"easing":"cubic-bezier(0.2, 0.6, 0.0, 1)","fill":"both"}] [{"selector":"#anim-a7f19223-c6d4-4666-aa77-960ed5d33462","keyframes":{"transform":["translate3d(-117.84387%, 0px, 0)","translate3d(0px, 0px, 0)"]},"delay":0,"duration":600,"easing":"cubic-bezier(0.2, 0.6, 0.0, 1)","fill":"both"}] [{"selector":"#anim-47e31f4e-38cb-43ad-8081-b6b7d6690fb5","keyframes":{"opacity":[0,1]},"delay":0,"duration":1000,"easing":"cubic-bezier(0.2, 0.6, 0.0, 1)","fill":"both"}] [{"selector":"#anim-2971cb0d-ea0e-4d93-9229-a8bab781d313","keyframes":{"transform":["translate3d(0px, 867.28444%, 0)","translate3d(0px, 0px, 0)"]},"delay":0,"duration":1000,"easing":"cubic-bezier(0.2, 0.6, 0.0, 1)","fill":"both"}] Nataliya Vaitkevich/Pexels leia mais em