DNA "lixo" pode ter papel fundamental no desenvolvimento humano, diz estudo

[{"selector":"#anim-29b67cab-1cee-4afb-8c43-cb8d872b86e0","keyframes":{"opacity":[0,1]},"delay":0,"duration":1000,"easing":"cubic-bezier(0.4, 0.4, 0.0, 1)","fill":"both"}] [{"selector":"#anim-249a2b88-5d0c-4431-aca8-44684308bd73","keyframes":{"opacity":[0,1]},"delay":0,"duration":500,"easing":"cubic-bezier(.3,0,.55,1)","fill":"both"}] [{"selector":"#anim-de527427-f056-40c0-aa16-7e39cb4eb2a4","keyframes":{"transform":["scale(0.3333333333333333)","scale(1)"]},"delay":0,"duration":500,"easing":"cubic-bezier(.3,0,.55,1)","fill":"forwards"}] [{"selector":"#anim-8cb1b013-c7b1-429f-8cec-99bcf4ccfb00","keyframes":{"opacity":[0,1]},"delay":0,"duration":600,"easing":"cubic-bezier(0.4, 0.4, 0.0, 1)","fill":"both"}] Unsplash

[{"selector":"#anim-b9260218-0847-4fa4-90ae-2121f20d5904","keyframes":{"opacity":[0,1]},"delay":0,"duration":1500,"easing":"cubic-bezier(0.4, 0.4, 0.0, 1)","fill":"both"}] [{"selector":"#anim-ebc8475b-fa71-4c4d-bab6-4b9261be715e","keyframes":{"opacity":[0,1]},"delay":0,"duration":500,"easing":"cubic-bezier(.3,0,.55,1)","fill":"both"}] [{"selector":"#anim-d0e7b715-ae7a-485c-a0d9-de1d10a50039","keyframes":{"transform":["scale(0.3333333333333333)","scale(1)"]},"delay":0,"duration":500,"easing":"cubic-bezier(.3,0,.55,1)","fill":"forwards"}] [{"selector":"#anim-a977827d-a4ff-455c-98f4-221b7acc3059","keyframes":{"opacity":[0,1]},"delay":0,"duration":600,"easing":"cubic-bezier(0.4, 0.4, 0.0, 1)","fill":"both"}] O genoma humano contém cerca de 8% de DNA proveniente de antigos vírus que se incorporaram ao nosso código genético, muitos deles presentes em elementos transponíveis (TEs), antes considerados “DNA lixo” Unsplash

[{"selector":"#anim-12d16f0f-f9a9-4635-95c0-86787d62f37f","keyframes":{"opacity":[0,1]},"delay":0,"duration":1500,"easing":"cubic-bezier(0.4, 0.4, 0.0, 1)","fill":"both"}] [{"selector":"#anim-fdd5b54d-f3b4-4c7a-8849-c1b995d2f3c1","keyframes":{"opacity":[0,1]},"delay":0,"duration":500,"easing":"cubic-bezier(.3,0,.55,1)","fill":"both"}] [{"selector":"#anim-f2bfd85b-87ca-40e4-9540-a7e759e1d64f","keyframes":{"transform":["scale(0.3333333333333333)","scale(1)"]},"delay":0,"duration":500,"easing":"cubic-bezier(.3,0,.55,1)","fill":"forwards"}] [{"selector":"#anim-463f54bf-017f-4a1b-95eb-11fc9148cc57","keyframes":{"opacity":[0,1]},"delay":0,"duration":600,"easing":"cubic-bezier(0.4, 0.4, 0.0, 1)","fill":"both"}] Um novo estudo revelou que esses TEs têm papel importante na regulação gênica e podem influenciar o desenvolvimento inicial e a evolução humana Unsplash

[{"selector":"#anim-9e22d21d-1dc3-490f-b571-5796dc047bc6","keyframes":{"opacity":[0,1]},"delay":0,"duration":1500,"easing":"cubic-bezier(0.4, 0.4, 0.0, 1)","fill":"both"}] [{"selector":"#anim-934f1074-1ef5-4962-b0bd-d04840898749","keyframes":{"opacity":[0,1]},"delay":0,"duration":500,"easing":"cubic-bezier(.3,0,.55,1)","fill":"both"}] [{"selector":"#anim-f8ed455f-7cd1-4fc1-a20e-111dcb2ee9f1","keyframes":{"transform":["scale(0.3333333333333333)","scale(1)"]},"delay":0,"duration":500,"easing":"cubic-bezier(.3,0,.55,1)","fill":"forwards"}] [{"selector":"#anim-1deaf556-5e18-4232-9bf6-329f1ac15ab9","keyframes":{"opacity":[0,1]},"delay":0,"duration":600,"easing":"cubic-bezier(0.4, 0.4, 0.0, 1)","fill":"both"}] Pesquisadores identificaram quatro novas subfamílias de um grupo de TEs chamado MER11, sendo a mais recente, MER11_G4, capaz de ativar fortemente genes em células-tronco e neurais Unsplash

[{"selector":"#anim-77f7da6a-1337-4756-8db9-e7dccdca1366","keyframes":{"opacity":[0,1]},"delay":0,"duration":1500,"easing":"cubic-bezier(0.4, 0.4, 0.0, 1)","fill":"both"}] [{"selector":"#anim-15fded21-a9bb-46ea-9ddc-b19ba2efbba9","keyframes":{"opacity":[0,1]},"delay":0,"duration":500,"easing":"cubic-bezier(.3,0,.55,1)","fill":"both"}] [{"selector":"#anim-f3a3384b-81a7-49f7-a51d-c9941e61c592","keyframes":{"transform":["scale(0.3333333333333333)","scale(1)"]},"delay":0,"duration":500,"easing":"cubic-bezier(.3,0,.55,1)","fill":"forwards"}] [{"selector":"#anim-b5765144-f4f1-42fc-8bed-e061ec24ff22","keyframes":{"opacity":[0,1]},"delay":0,"duration":600,"easing":"cubic-bezier(0.4, 0.4, 0.0, 1)","fill":"both"}] Essas sequências parecem ter evoluído de formas diferentes em primatas, contribuindo para diferenças biológicas entre humanos, chimpanzés e macacos Unsplash

[{"selector":"#anim-58b0deec-0320-4c2d-bdb7-6d9eb65d3aa2","keyframes":{"opacity":[0,1]},"delay":0,"duration":1500,"easing":"cubic-bezier(0.4, 0.4, 0.0, 1)","fill":"both"}] [{"selector":"#anim-c3bc45fd-aa1d-4690-bce1-37f15f160fb2","keyframes":{"opacity":[0,1]},"delay":0,"duration":500,"easing":"cubic-bezier(.3,0,.55,1)","fill":"both"}] [{"selector":"#anim-5217d83d-5806-4038-93cb-f5f396fabc63","keyframes":{"transform":["scale(0.3333333333333333)","scale(1)"]},"delay":0,"duration":500,"easing":"cubic-bezier(.3,0,.55,1)","fill":"forwards"}] [{"selector":"#anim-0ef5f72f-9829-4655-9573-09a4fe7886e1","keyframes":{"opacity":[0,1]},"delay":0,"duration":600,"easing":"cubic-bezier(0.4, 0.4, 0.0, 1)","fill":"both"}] Embora a maioria dos TEs esteja inativa, alguns podem estar ligados a doenças humanas e também oferecer potencial para terapias gênicas Unsplash

[{"selector":"#anim-e9db846e-a79d-459c-a319-f2848c526af0","keyframes":{"opacity":[0,1]},"delay":0,"duration":1500,"easing":"cubic-bezier(0.4, 0.4, 0.0, 1)","fill":"both"}] [{"selector":"#anim-e6563977-84ed-42e9-8a92-c965b7528b2c","keyframes":{"opacity":[0,1]},"delay":0,"duration":500,"easing":"cubic-bezier(.3,0,.55,1)","fill":"both"}] [{"selector":"#anim-e3eeeef1-0db7-4976-b1b3-0994c1bef20e","keyframes":{"transform":["scale(0.3333333333333333)","scale(1)"]},"delay":0,"duration":500,"easing":"cubic-bezier(.3,0,.55,1)","fill":"forwards"}] [{"selector":"#anim-1be264c3-3006-4a2b-9e79-89dcc52e896e","keyframes":{"opacity":[0,1]},"delay":0,"duration":600,"easing":"cubic-bezier(0.4, 0.4, 0.0, 1)","fill":"both"}] O estudo reforça que entender a função desses genes “saltadores” pode esclarecer a evolução do genoma, a origem de doenças e abrir caminhos para novas intervenções médicas Unsplash

CNNBRASIL.COM.BR

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