Paracetamol: descoberta sobre ação pode levar a analgésico mais seguro

Descoberta sobre ação do paracetamol pode levar a analgésicos mais seguros

[{"selector":"#anim-37b0523d-1cae-4397-add1-e3370e96e0a2","keyframes":{"opacity":[0,1]},"delay":0,"duration":1000,"easing":"cubic-bezier(0.4, 0.4, 0.0, 1)","fill":"both"}] [{"selector":"#anim-941f012b-49a5-487b-b99a-3562afb827a1","keyframes":{"opacity":[0,1]},"delay":0,"duration":500,"easing":"cubic-bezier(.3,0,.55,1)","fill":"both"}] [{"selector":"#anim-55dde475-5ece-4d6a-8665-d465f6067513","keyframes":{"transform":["scale(0.3333333333333333)","scale(1)"]},"delay":0,"duration":500,"easing":"cubic-bezier(.3,0,.55,1)","fill":"forwards"}] [{"selector":"#anim-bfd6f088-fd83-4650-930d-b8e0178b264c","keyframes":{"opacity":[0,1]},"delay":0,"duration":600,"easing":"cubic-bezier(0.4, 0.4, 0.0, 1)","fill":"both"}] Unsplash

[{"selector":"#anim-7c4b4d0a-bfaa-4b80-aec5-b061721bff5f","keyframes":{"opacity":[0,1]},"delay":0,"duration":1500,"easing":"cubic-bezier(0.4, 0.4, 0.0, 1)","fill":"both"}] [{"selector":"#anim-c49c89d0-6244-4d54-8c95-c05eec77260d","keyframes":{"opacity":[0,1]},"delay":0,"duration":500,"easing":"cubic-bezier(.3,0,.55,1)","fill":"both"}] [{"selector":"#anim-39eebd73-5c96-4755-8a5b-ca06462f8b22","keyframes":{"transform":["scale(0.3333333333333333)","scale(1)"]},"delay":0,"duration":500,"easing":"cubic-bezier(.3,0,.55,1)","fill":"forwards"}] [{"selector":"#anim-573e0f34-6edb-48c7-81fb-941c4b20dab5","keyframes":{"opacity":[0,1]},"delay":0,"duration":600,"easing":"cubic-bezier(0.4, 0.4, 0.0, 1)","fill":"both"}] [{"selector":"#anim-53d5c2a0-e918-478e-824d-85cc7ad3392f [data-leaf-element=\"true\"]","keyframes":{"transform":["translate3d(32.385097723411796%, 0, 0)","translate3d(0%, 0, 0)"]},"delay":0,"duration":2000,"easing":"cubic-bezier(.3,0,.55,1)","fill":"both"}] O paracetamol , usado há mais de 70 anos contra dor e febre, sempre teve seu mecanismo de ação pouco compreendido Unsplash

[{"selector":"#anim-35346bd5-d518-4e45-a358-0fd4d6f05408","keyframes":{"opacity":[0,1]},"delay":0,"duration":1500,"easing":"cubic-bezier(0.4, 0.4, 0.0, 1)","fill":"both"}] [{"selector":"#anim-620bdfdb-b79d-4f62-9cf5-74730e52ad29","keyframes":{"opacity":[0,1]},"delay":0,"duration":500,"easing":"cubic-bezier(.3,0,.55,1)","fill":"both"}] [{"selector":"#anim-7e456a0a-ba60-4a51-88ac-fbf2cec52127","keyframes":{"transform":["scale(0.3333333333333333)","scale(1)"]},"delay":0,"duration":500,"easing":"cubic-bezier(.3,0,.55,1)","fill":"forwards"}] [{"selector":"#anim-b3db3c0c-b34f-4f3f-af4f-fb9f3cd86622","keyframes":{"opacity":[0,1]},"delay":0,"duration":600,"easing":"cubic-bezier(0.4, 0.4, 0.0, 1)","fill":"both"}] [{"selector":"#anim-63fa13e6-56de-4c51-8271-890f4b14b3c1 [data-leaf-element=\"true\"]","keyframes":{"transform":["translate3d(0, 29.5774647887324%, 0)","translate3d(0, 0%, 0)"]},"delay":0,"duration":2000,"easing":"cubic-bezier(.3,0,.55,1)","fill":"both"}] Um novo estudo da Universidade de Indiana mostrou que ele não aumenta, mas reduz a ação de um endocanabinoide chamado 2-AG Unsplash

[{"selector":"#anim-e492e7b7-6dd5-4e26-bf4a-97caca67e871","keyframes":{"opacity":[0,1]},"delay":0,"duration":1500,"easing":"cubic-bezier(0.4, 0.4, 0.0, 1)","fill":"both"}] [{"selector":"#anim-47bf24d9-2ea8-4f7a-af72-d3aec370dc7e","keyframes":{"opacity":[0,1]},"delay":0,"duration":500,"easing":"cubic-bezier(.3,0,.55,1)","fill":"both"}] [{"selector":"#anim-09af09dd-a348-48ec-8b71-980552d9cb63","keyframes":{"transform":["scale(0.3333333333333333)","scale(1)"]},"delay":0,"duration":500,"easing":"cubic-bezier(.3,0,.55,1)","fill":"forwards"}] [{"selector":"#anim-e1b71152-80a5-4b09-bfb8-4c7fed2b6b74","keyframes":{"opacity":[0,1]},"delay":0,"duration":600,"easing":"cubic-bezier(0.4, 0.4, 0.0, 1)","fill":"both"}] [{"selector":"#anim-5b2a02b2-fd9c-4faf-a9e2-e2d7b6ad8c8f [data-leaf-element=\"true\"]","keyframes":{"transform":["translate3d(31.249999886225726%, 0, 0)","translate3d(0%, 0, 0)"]},"delay":0,"duration":2000,"easing":"cubic-bezier(.3,0,.55,1)","fill":"both"}] Essa substância, até então associada ao alívio da dor, mostrou ter efeito oposto quando em excesso Unsplash

[{"selector":"#anim-cbd8b7be-e9d6-4ac1-a71f-47cbeaaf352e","keyframes":{"opacity":[0,1]},"delay":0,"duration":1500,"easing":"cubic-bezier(0.4, 0.4, 0.0, 1)","fill":"both"}] [{"selector":"#anim-a50cd2bd-a7b1-4641-9548-f7fbfa080e95","keyframes":{"opacity":[0,1]},"delay":0,"duration":500,"easing":"cubic-bezier(.3,0,.55,1)","fill":"both"}] [{"selector":"#anim-0af7ac32-ccf3-4157-bfc7-f9fe76289c26","keyframes":{"transform":["scale(0.3333333333333333)","scale(1)"]},"delay":0,"duration":500,"easing":"cubic-bezier(.3,0,.55,1)","fill":"forwards"}] [{"selector":"#anim-5b57e83e-c995-491d-9311-f142aa5313fe","keyframes":{"opacity":[0,1]},"delay":0,"duration":600,"easing":"cubic-bezier(0.4, 0.4, 0.0, 1)","fill":"both"}] [{"selector":"#anim-0f23be0c-e745-423d-9ef0-936cd5569f9f [data-leaf-element=\"true\"]","keyframes":{"transform":["translate(0%, 0%) scale(1.5)","translate(0%, 0%) scale(1)"]},"delay":0,"duration":2000,"easing":"cubic-bezier(.3,0,.55,1)","fill":"forwards"}] O paracetamol age bloqueando a enzima responsável pela produção de 2-AG, o que diminui a sensação de dor Unsplash

[{"selector":"#anim-a10816da-c4bd-419b-9867-81b22d63ff68","keyframes":{"opacity":[0,1]},"delay":0,"duration":1500,"easing":"cubic-bezier(0.4, 0.4, 0.0, 1)","fill":"both"}] [{"selector":"#anim-8792784f-da67-47cb-8fc9-3b04e582a305","keyframes":{"opacity":[0,1]},"delay":0,"duration":500,"easing":"cubic-bezier(.3,0,.55,1)","fill":"both"}] [{"selector":"#anim-7033b49f-eb12-48c1-9617-015980bf60ae","keyframes":{"transform":["scale(0.3333333333333333)","scale(1)"]},"delay":0,"duration":500,"easing":"cubic-bezier(.3,0,.55,1)","fill":"forwards"}] [{"selector":"#anim-d737b3e5-8263-47b8-b403-5432b4b1d3f1","keyframes":{"opacity":[0,1]},"delay":0,"duration":600,"easing":"cubic-bezier(0.4, 0.4, 0.0, 1)","fill":"both"}] [{"selector":"#anim-e19b632c-6174-4b8f-bbff-3409540c3559 [data-leaf-element=\"true\"]","keyframes":{"transform":["translate3d(7.812499744007886%, 0, 0)","translate3d(0%, 0, 0)"]},"delay":0,"duration":2000,"easing":"cubic-bezier(.3,0,.55,1)","fill":"both"}] A descoberta rompe com décadas de entendimento científico e abre caminho para o desenvolvimento de analgésicos mais eficazes e menos tóxicos Unsplash

[{"selector":"#anim-b6ba561f-e6ba-4319-a196-670db5ab4bdc","keyframes":{"opacity":[0,1]},"delay":0,"duration":1500,"easing":"cubic-bezier(0.4, 0.4, 0.0, 1)","fill":"both"}] [{"selector":"#anim-592dc46b-0749-4756-bc3b-da1ebe9811a5","keyframes":{"opacity":[0,1]},"delay":0,"duration":500,"easing":"cubic-bezier(.3,0,.55,1)","fill":"both"}] [{"selector":"#anim-a4c07813-3137-4730-91f4-6ea4f310e804","keyframes":{"transform":["scale(0.3333333333333333)","scale(1)"]},"delay":0,"duration":500,"easing":"cubic-bezier(.3,0,.55,1)","fill":"forwards"}] [{"selector":"#anim-3cdca602-31e3-4633-9278-ff5e2ac17a54","keyframes":{"opacity":[0,1]},"delay":0,"duration":600,"easing":"cubic-bezier(0.4, 0.4, 0.0, 1)","fill":"both"}] [{"selector":"#anim-fa26be6c-b859-411f-963a-69f382805e04 [data-leaf-element=\"true\"]","keyframes":{"transform":["translate3d(-32.37742818055872%, 0, 0)","translate3d(0%, 0, 0)"]},"delay":0,"duration":2000,"easing":"cubic-bezier(.3,0,.55,1)","fill":"both"}] Isso é relevante porque a overdose do medicamento é responsável por centenas de mortes e é a segunda principal causa de transplante de fígado no mundo Unsplash

CNNBRASIL.COM.BR

[{"selector":"#anim-9e666285-165c-45b5-82f4-f424e7323aa5","keyframes":{"opacity":[0,1]},"delay":0,"duration":600,"easing":"cubic-bezier(0.4, 0.4, 0.0, 1)","fill":"both"}] [{"selector":"#anim-90dea535-0b33-40b7-91fd-f32341655a26","keyframes":{"opacity":[0,1]},"delay":0,"duration":600,"easing":"cubic-bezier(0.4, 0.4, 0.0, 1)","fill":"both"}] [{"selector":"#anim-fade33c4-0a4a-4c3b-bda2-97fa8ae86283","keyframes":{"opacity":[0,1]},"delay":0,"duration":1000,"easing":"cubic-bezier(0.2, 0.6, 0.0, 1)","fill":"both"}] [{"selector":"#anim-3e430f96-d8e4-4ba6-bba4-c51491a67d76","keyframes":{"transform":["translate3d(0px, 2132.63615%, 0)","translate3d(0px, 0px, 0)"]},"delay":0,"duration":1000,"easing":"cubic-bezier(0.2, 0.6, 0.0, 1)","fill":"both"}] [{"selector":"#anim-6908db46-f156-4219-a472-2b8d53c27e24","keyframes":{"opacity":[0,1]},"delay":0,"duration":600,"easing":"cubic-bezier(0.2, 0.6, 0.0, 1)","fill":"both"}] [{"selector":"#anim-212c9a0a-3049-4b63-9824-8c997b45285b","keyframes":{"transform":["translate3d(-117.84387%, 0px, 0)","translate3d(0px, 0px, 0)"]},"delay":0,"duration":600,"easing":"cubic-bezier(0.2, 0.6, 0.0, 1)","fill":"both"}] [{"selector":"#anim-e9ba8a3c-44fa-4bc2-b2a4-51107b159060","keyframes":{"opacity":[0,1]},"delay":0,"duration":1000,"easing":"cubic-bezier(0.2, 0.6, 0.0, 1)","fill":"both"}] [{"selector":"#anim-13ba2c7e-8d2f-4b8d-9b6f-1e8db4d8b5fc","keyframes":{"transform":["translate3d(0px, 1223.93157%, 0)","translate3d(0px, 0px, 0)"]},"delay":0,"duration":1000,"easing":"cubic-bezier(0.2, 0.6, 0.0, 1)","fill":"both"}] Unsplash leia mais em