Autismo pode ser um efeito colateral da evolução do cérebro humano; entenda

[{"selector":"#anim-697726b6-a054-456d-a9ee-9354ceda8106","keyframes":{"opacity":[0,1]},"delay":0,"duration":1000,"easing":"cubic-bezier(0.4, 0.4, 0.0, 1)","fill":"both"}] [{"selector":"#anim-8beccbda-41af-40c7-a9e4-96c7be59a933","keyframes":{"opacity":[0,1]},"delay":0,"duration":500,"easing":"cubic-bezier(.3,0,.55,1)","fill":"both"}] [{"selector":"#anim-50eaf417-cb5a-4ae4-96cf-26b19d4474de","keyframes":{"transform":["scale(0.3333333333333333)","scale(1)"]},"delay":0,"duration":500,"easing":"cubic-bezier(.3,0,.55,1)","fill":"forwards"}] [{"selector":"#anim-49a9372f-887b-4ad5-b4db-dfd03f8361f5","keyframes":{"opacity":[0,1]},"delay":0,"duration":600,"easing":"cubic-bezier(0.4, 0.4, 0.0, 1)","fill":"both"}] Unsplash

[{"selector":"#anim-b70825a0-7344-4c55-9c0c-46e6466505f8","keyframes":{"opacity":[0,1]},"delay":0,"duration":1500,"easing":"cubic-bezier(0.4, 0.4, 0.0, 1)","fill":"both"}] [{"selector":"#anim-4c1c0309-3bef-4601-8559-194e93585e6b","keyframes":{"opacity":[0,1]},"delay":0,"duration":500,"easing":"cubic-bezier(.3,0,.55,1)","fill":"both"}] [{"selector":"#anim-386b4c41-6d26-4161-9747-c331c8d7f18e","keyframes":{"transform":["scale(0.3333333333333333)","scale(1)"]},"delay":0,"duration":500,"easing":"cubic-bezier(.3,0,.55,1)","fill":"forwards"}] [{"selector":"#anim-e020666a-9661-460b-8e51-218b9b7568f4","keyframes":{"opacity":[0,1]},"delay":0,"duration":600,"easing":"cubic-bezier(0.4, 0.4, 0.0, 1)","fill":"both"}] Pesquisadores de Stanford identificaram uma possível relação entre a evolução acelerada de determinados neurônios do cérebro humano e a maior vulnerabilidade ao autismo Unsplash

[{"selector":"#anim-265ca26b-e992-4f24-a139-d9342f408047","keyframes":{"opacity":[0,1]},"delay":0,"duration":1500,"easing":"cubic-bezier(0.4, 0.4, 0.0, 1)","fill":"both"}] [{"selector":"#anim-84fde17c-9de3-4452-b828-3916db39c692","keyframes":{"opacity":[0,1]},"delay":0,"duration":500,"easing":"cubic-bezier(.3,0,.55,1)","fill":"both"}] [{"selector":"#anim-48b1d27e-f962-4b9a-8c10-c86528cb27cd","keyframes":{"transform":["scale(0.3333333333333333)","scale(1)"]},"delay":0,"duration":500,"easing":"cubic-bezier(.3,0,.55,1)","fill":"forwards"}] [{"selector":"#anim-c8c215b9-9ac9-4147-a02e-f849a40ef5dc","keyframes":{"opacity":[0,1]},"delay":0,"duration":600,"easing":"cubic-bezier(0.4, 0.4, 0.0, 1)","fill":"both"}] O estudo analisou os neurônios L2/3 IT, presentes nas camadas externas do córtex cerebral e envolvidos em funções cognitivas complexas, como linguagem, memória e raciocínio Unsplash

[{"selector":"#anim-ea19c9e9-1ec5-44cc-80b7-bdf2666ee1cc","keyframes":{"opacity":[0,1]},"delay":0,"duration":1500,"easing":"cubic-bezier(0.4, 0.4, 0.0, 1)","fill":"both"}] [{"selector":"#anim-463042b2-c374-42e2-954f-e0f2c15cef5b","keyframes":{"opacity":[0,1]},"delay":0,"duration":500,"easing":"cubic-bezier(.3,0,.55,1)","fill":"both"}] [{"selector":"#anim-a4280423-0ea5-47b6-9342-4a7ce5997a37","keyframes":{"transform":["scale(0.3333333333333333)","scale(1)"]},"delay":0,"duration":500,"easing":"cubic-bezier(.3,0,.55,1)","fill":"forwards"}] [{"selector":"#anim-5cfd3d26-75a5-4f53-ac83-e23076e30240","keyframes":{"opacity":[0,1]},"delay":0,"duration":600,"easing":"cubic-bezier(0.4, 0.4, 0.0, 1)","fill":"both"}] Em geral, neurônios mais abundantes tendem a evoluir mais lentamente, mas os L2/3 IT apresentaram uma evolução excepcionalmente rápida na linhagem humana Unsplash

[{"selector":"#anim-2cbb5a48-df42-4204-ba0c-4e19d7995604","keyframes":{"opacity":[0,1]},"delay":0,"duration":1500,"easing":"cubic-bezier(0.4, 0.4, 0.0, 1)","fill":"both"}] [{"selector":"#anim-a4a3396c-47e3-4563-a85e-9ecaeaad8154","keyframes":{"opacity":[0,1]},"delay":0,"duration":500,"easing":"cubic-bezier(.3,0,.55,1)","fill":"both"}] [{"selector":"#anim-64236a79-5a12-4f58-9570-48b0394eb1e3","keyframes":{"transform":["scale(0.3333333333333333)","scale(1)"]},"delay":0,"duration":500,"easing":"cubic-bezier(.3,0,.55,1)","fill":"forwards"}] [{"selector":"#anim-10863643-6e67-4f0c-a40c-ad7fd893dd07","keyframes":{"opacity":[0,1]},"delay":0,"duration":600,"easing":"cubic-bezier(0.4, 0.4, 0.0, 1)","fill":"both"}] Os pesquisadores também observaram alterações coordenadas em centenas de genes associados ao autismo, incluindo uma redução significativa na expressão de 34 deles Unsplash

[{"selector":"#anim-f16779bb-af99-47fc-a78e-2bbc1721a67e","keyframes":{"opacity":[0,1]},"delay":0,"duration":1500,"easing":"cubic-bezier(0.4, 0.4, 0.0, 1)","fill":"both"}] [{"selector":"#anim-bc459bf7-a20a-41ee-a5e2-dc5dfdd5f8bb","keyframes":{"opacity":[0,1]},"delay":0,"duration":500,"easing":"cubic-bezier(.3,0,.55,1)","fill":"both"}] [{"selector":"#anim-1b4d1219-5554-45fe-803e-a587e844ad97","keyframes":{"transform":["scale(0.3333333333333333)","scale(1)"]},"delay":0,"duration":500,"easing":"cubic-bezier(.3,0,.55,1)","fill":"forwards"}] [{"selector":"#anim-5cda1fbd-5bbf-4050-938d-a6e165619479","keyframes":{"opacity":[0,1]},"delay":0,"duration":600,"easing":"cubic-bezier(0.4, 0.4, 0.0, 1)","fill":"both"}] A hipótese é que mudanças que favoreceram características do cérebro humano também possam ter aumentado sua vulnerabilidade a condições neuropsiquiátricas, representando um possível “trade-off” evolutivo Unsplash

[{"selector":"#anim-33ecb2dd-2e57-4157-85b3-f6f95e17fc89","keyframes":{"opacity":[0,1]},"delay":0,"duration":1500,"easing":"cubic-bezier(0.4, 0.4, 0.0, 1)","fill":"both"}] [{"selector":"#anim-d1f7824d-77b5-4920-9b70-6410d716f593","keyframes":{"opacity":[0,1]},"delay":0,"duration":500,"easing":"cubic-bezier(.3,0,.55,1)","fill":"both"}] [{"selector":"#anim-3eebf6fb-4ab5-4a3d-af3d-b713d10a533f","keyframes":{"transform":["scale(0.3333333333333333)","scale(1)"]},"delay":0,"duration":500,"easing":"cubic-bezier(.3,0,.55,1)","fill":"forwards"}] [{"selector":"#anim-38063607-1599-4992-bb53-d0290b46750a","keyframes":{"opacity":[0,1]},"delay":0,"duration":600,"easing":"cubic-bezier(0.4, 0.4, 0.0, 1)","fill":"both"}] Os resultados podem orientar novas pesquisas sobre a origem do autismo e, futuramente, contribuir para o desenvolvimento de biomarcadores e tratamentos mais específicos Unsplash

CNNBRASIL.COM.BR

[{"selector":"#anim-addec31f-cfc6-4e65-baf3-ed383329fa59","keyframes":{"opacity":[0,1]},"delay":0,"duration":600,"easing":"cubic-bezier(0.4, 0.4, 0.0, 1)","fill":"both"}] [{"selector":"#anim-bac11ecc-c2f7-4866-92b6-27544c90dc3e","keyframes":{"opacity":[0,1]},"delay":0,"duration":600,"easing":"cubic-bezier(0.4, 0.4, 0.0, 1)","fill":"both"}] [{"selector":"#anim-d711a89c-6e9b-4a1e-9e23-2846e1f1b17f","keyframes":{"opacity":[0,1]},"delay":0,"duration":1000,"easing":"cubic-bezier(0.2, 0.6, 0.0, 1)","fill":"both"}] [{"selector":"#anim-9d1cbd10-77e3-49bf-a7d0-1353b3af8e46","keyframes":{"transform":["translate3d(0px, 2132.63615%, 0)","translate3d(0px, 0px, 0)"]},"delay":0,"duration":1000,"easing":"cubic-bezier(0.2, 0.6, 0.0, 1)","fill":"both"}] [{"selector":"#anim-42815124-56e6-469c-b329-7f5feb516b9b","keyframes":{"opacity":[0,1]},"delay":0,"duration":600,"easing":"cubic-bezier(0.2, 0.6, 0.0, 1)","fill":"both"}] [{"selector":"#anim-f47181fc-c400-4b75-9069-21bae68f21d0","keyframes":{"transform":["translate3d(-117.84387%, 0px, 0)","translate3d(0px, 0px, 0)"]},"delay":0,"duration":600,"easing":"cubic-bezier(0.2, 0.6, 0.0, 1)","fill":"both"}] [{"selector":"#anim-f45f1f0d-184d-4497-b82a-39fd5442c4c5","keyframes":{"opacity":[0,1]},"delay":0,"duration":1000,"easing":"cubic-bezier(0.2, 0.6, 0.0, 1)","fill":"both"}] [{"selector":"#anim-5b38d818-bc61-4a1f-8975-8ff997c8f49a","keyframes":{"transform":["translate3d(0px, 1223.93157%, 0)","translate3d(0px, 0px, 0)"]},"delay":0,"duration":1000,"easing":"cubic-bezier(0.2, 0.6, 0.0, 1)","fill":"both"}] Unsplash leia mais em