Biópsia líquida avança como meio para detectar mutações em câncer

Biópsia líquida avança como meio para detectar mutações em câncer de pulmão

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[{"selector":"#anim-ec337acb-290a-43e2-acef-67500843f677","keyframes":{"opacity":[0,1]},"delay":0,"duration":1500,"easing":"cubic-bezier(0.4, 0.4, 0.0, 1)","fill":"both"}] [{"selector":"#anim-0537ae49-3408-4a79-a722-4dc06f8fa4ef","keyframes":{"opacity":[0,1]},"delay":0,"duration":600,"easing":"cubic-bezier(0.4, 0.4, 0.0, 1)","fill":"both"}] [{"selector":"#anim-dc85f287-3d9f-4daa-a997-af5fe6a90d6d","keyframes":{"opacity":[0,1]},"delay":0,"duration":500,"easing":"cubic-bezier(.3,0,.55,1)","fill":"both"}] [{"selector":"#anim-4725cd87-cc7e-4b23-9814-ef8dc8570639","keyframes":{"transform":["scale(0.3333333333333333)","scale(1)"]},"delay":0,"duration":500,"easing":"cubic-bezier(.3,0,.55,1)","fill":"forwards"}] [{"selector":"#anim-6033612b-ad61-4241-9359-1e714536b486 [data-leaf-element=\"true\"]","keyframes":{"transform":["translate3d(-48.158482125038184%, 0, 0)","translate3d(0%, 0, 0)"]},"delay":0,"duration":2000,"easing":"cubic-bezier(.3,0,.55,1)","fill":"both"}] A detecção precoce de alterações genéticas no câncer de pulmão por meio de biópsia líquida pode se tornar uma ferramenta importante para acelerar o diagnóstico e orientar o tratamento de pacientes no Brasil Aakash Dhage/Unsplash

[{"selector":"#anim-cf1bbbb9-6ebb-4bd0-b5f4-c134b45f2fbe","keyframes":{"opacity":[0,1]},"delay":0,"duration":1500,"easing":"cubic-bezier(0.4, 0.4, 0.0, 1)","fill":"both"}] [{"selector":"#anim-f58d5724-940a-4b8d-a131-5a549bf688c3","keyframes":{"opacity":[0,1]},"delay":0,"duration":600,"easing":"cubic-bezier(0.4, 0.4, 0.0, 1)","fill":"both"}] [{"selector":"#anim-4bdad409-fdae-4ff2-8af5-b9570dcb7f2f","keyframes":{"opacity":[0,1]},"delay":0,"duration":500,"easing":"cubic-bezier(.3,0,.55,1)","fill":"both"}] [{"selector":"#anim-9bded18b-99e6-4511-ba6e-41242635ef1b","keyframes":{"transform":["scale(0.3333333333333333)","scale(1)"]},"delay":0,"duration":500,"easing":"cubic-bezier(.3,0,.55,1)","fill":"forwards"}] Um estudo apoiado pela Fapesp e publicado na revista Molecular Oncology mostrou que é possível identificar mutações relevantes em amostras de sangue de pacientes com câncer de pulmão não pequenas células usando um painel multigênico comercial Los Muertos Crew/Pexels

[{"selector":"#anim-8abbb526-fa7e-47d1-aadc-6102a502d9a0","keyframes":{"opacity":[0,1]},"delay":0,"duration":1500,"easing":"cubic-bezier(0.4, 0.4, 0.0, 1)","fill":"both"}] [{"selector":"#anim-2e105d26-a212-44a3-b73c-d7b63d6c4afc","keyframes":{"opacity":[0,1]},"delay":0,"duration":600,"easing":"cubic-bezier(0.4, 0.4, 0.0, 1)","fill":"both"}] [{"selector":"#anim-ac56ad2b-8ac7-427c-adba-0dfd16625854","keyframes":{"opacity":[0,1]},"delay":0,"duration":500,"easing":"cubic-bezier(.3,0,.55,1)","fill":"both"}] [{"selector":"#anim-41d6ea08-1ba5-40ae-b0c6-81c46d9eed75","keyframes":{"transform":["scale(0.3333333333333333)","scale(1)"]},"delay":0,"duration":500,"easing":"cubic-bezier(.3,0,.55,1)","fill":"forwards"}] O câncer de pulmão não pequenas células representa cerca de 85% dos casos da doença, sendo o subtipo mais prevalente. Dentro dele, há diferentes grupos, como o adenocarcinoma e o carcinoma de células escamosas Anna Shvets/Pexels

[{"selector":"#anim-7bd01055-67a9-4c9f-8b93-efa5db5c6409","keyframes":{"opacity":[0,1]},"delay":0,"duration":1500,"easing":"cubic-bezier(0.4, 0.4, 0.0, 1)","fill":"both"}] [{"selector":"#anim-8f3af8ee-9e3c-46d4-8fa5-4adab0abad31","keyframes":{"opacity":[0,1]},"delay":0,"duration":600,"easing":"cubic-bezier(0.4, 0.4, 0.0, 1)","fill":"both"}] [{"selector":"#anim-4d71f196-f9f6-4427-b304-52500d701984","keyframes":{"opacity":[0,1]},"delay":0,"duration":500,"easing":"cubic-bezier(.3,0,.55,1)","fill":"both"}] [{"selector":"#anim-b856d5d7-87e5-4d94-83ae-ef5f8a7ff8e4","keyframes":{"transform":["scale(0.3333333333333333)","scale(1)"]},"delay":0,"duration":500,"easing":"cubic-bezier(.3,0,.55,1)","fill":"forwards"}] [{"selector":"#anim-f069a695-4449-4239-a953-cd81f46725fc [data-leaf-element=\"true\"]","keyframes":{"transform":["translate3d(-31.249999886225726%, 0, 0)","translate3d(0%, 0, 0)"]},"delay":0,"duration":2000,"easing":"cubic-bezier(.3,0,.55,1)","fill":"both"}] Os pesquisadores usaram um painel comercial desenhado especificamente para mutações conhecidas no adenocarcinoma e buscaram alterações em 11 genes relacionados ao desenvolvimento do tumor Pixabay

[{"selector":"#anim-205eca14-3cec-4e3c-8c88-ea6fc1ef0274","keyframes":{"opacity":[0,1]},"delay":0,"duration":1500,"easing":"cubic-bezier(0.4, 0.4, 0.0, 1)","fill":"both"}] [{"selector":"#anim-c6eba7bf-fa0f-43a5-98de-4b4c05d6ea95","keyframes":{"opacity":[0,1]},"delay":0,"duration":600,"easing":"cubic-bezier(0.4, 0.4, 0.0, 1)","fill":"both"}] [{"selector":"#anim-ed65df7e-ada6-47a7-ae52-f74f90672db0","keyframes":{"opacity":[0,1]},"delay":0,"duration":500,"easing":"cubic-bezier(.3,0,.55,1)","fill":"both"}] [{"selector":"#anim-7ea793cd-c5cc-4901-92df-b12d47ce73cd","keyframes":{"transform":["scale(0.3333333333333333)","scale(1)"]},"delay":0,"duration":500,"easing":"cubic-bezier(.3,0,.55,1)","fill":"forwards"}] [{"selector":"#anim-58bee60b-c345-49ff-8a09-be6a282fc852 [data-leaf-element=\"true\"]","keyframes":{"transform":["translate3d(31.248514855328075%, 0, 0)","translate3d(0%, 0, 0)"]},"delay":0,"duration":2000,"easing":"cubic-bezier(.3,0,.55,1)","fill":"both"}] O desempenho da técnica surpreendeu: 65,6% das amostras apresentaram mutações, sendo que essa taxa chegou a 87,5% entre os pacientes que já tinham passado por alguma terapia Karola G/Pexels

[{"selector":"#anim-ce33fd40-650a-4653-a634-7eb26a89553e","keyframes":{"opacity":[0,1]},"delay":0,"duration":1500,"easing":"cubic-bezier(0.4, 0.4, 0.0, 1)","fill":"both"}] [{"selector":"#anim-04c0e2f1-7d5b-4a78-b0ad-7889091c8c45","keyframes":{"opacity":[0,1]},"delay":0,"duration":600,"easing":"cubic-bezier(0.4, 0.4, 0.0, 1)","fill":"both"}] [{"selector":"#anim-2ff49f23-cd95-4c93-8bcf-e762cbe0bb9e","keyframes":{"opacity":[0,1]},"delay":0,"duration":500,"easing":"cubic-bezier(.3,0,.55,1)","fill":"both"}] [{"selector":"#anim-198dfdf9-90ce-4dfe-bc13-e007818682f8","keyframes":{"transform":["scale(0.3333333333333333)","scale(1)"]},"delay":0,"duration":500,"easing":"cubic-bezier(.3,0,.55,1)","fill":"forwards"}] [{"selector":"#anim-0d992cfa-efeb-42bf-8f1f-e2726f92d844 [data-leaf-element=\"true\"]","keyframes":{"transform":["translate3d(0, 19.26663346004927%, 0)","translate3d(0, 0%, 0)"]},"delay":0,"duration":2000,"easing":"cubic-bezier(.3,0,.55,1)","fill":"both"}] Para os pesquisadores, isso demonstra o potencial da biópsia líquida como ferramenta complementar ao rastreamento de populações de risco, especialmente fumantes e ex-fumantes Muhammad Shamaoon Malik/Pexels

[{"selector":"#anim-01415f09-42dc-4cf0-8223-83ae48bd957e","keyframes":{"opacity":[0,1]},"delay":0,"duration":1500,"easing":"cubic-bezier(0.4, 0.4, 0.0, 1)","fill":"both"}] [{"selector":"#anim-f6760441-938d-4173-85d4-867c5b310014","keyframes":{"opacity":[0,1]},"delay":0,"duration":600,"easing":"cubic-bezier(0.4, 0.4, 0.0, 1)","fill":"both"}] [{"selector":"#anim-a2e17a97-e0d5-46b2-9e83-395c297a1077","keyframes":{"opacity":[0,1]},"delay":0,"duration":500,"easing":"cubic-bezier(.3,0,.55,1)","fill":"both"}] [{"selector":"#anim-942720b2-0f8b-4a17-92b7-67603c638247","keyframes":{"transform":["scale(0.3333333333333333)","scale(1)"]},"delay":0,"duration":500,"easing":"cubic-bezier(.3,0,.55,1)","fill":"forwards"}] [{"selector":"#anim-e2f041c6-cc34-41a6-b22d-698d3bdb1fe6 [data-leaf-element=\"true\"]","keyframes":{"transform":["translate3d(40.198058326199906%, 0, 0)","translate3d(0%, 0, 0)"]},"delay":0,"duration":2000,"easing":"cubic-bezier(.3,0,.55,1)","fill":"both"}] Enquanto a análise convencional do tumor obtido por biópsia ou cirurgia pode levar semanas entre coleta, processamento da amostra, avaliação em patologia e liberação do laudo, a biópsia líquida encurta consideravelmente esse caminho Freepick

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