Cientistas descobrem molécula que pode tratar alcoolismo

[{"selector":"#anim-e4b86832-128a-4a14-b162-5cf144f168ff","keyframes":{"opacity":[0,1]},"delay":0,"duration":1000,"easing":"cubic-bezier(0.4, 0.4, 0.0, 1)","fill":"both"}] [{"selector":"#anim-a0bd6b32-676e-47b3-924b-6ea1955a093f","keyframes":{"opacity":[0,1]},"delay":0,"duration":500,"easing":"cubic-bezier(.3,0,.55,1)","fill":"both"}] [{"selector":"#anim-48375f5a-a837-4e05-8648-2750e6417d1f","keyframes":{"transform":["scale(0.3333333333333333)","scale(1)"]},"delay":0,"duration":500,"easing":"cubic-bezier(.3,0,.55,1)","fill":"forwards"}] [{"selector":"#anim-4ef6ea3c-8a00-4ca3-a2cd-1d7923bb839f","keyframes":{"opacity":[0,1]},"delay":0,"duration":600,"easing":"cubic-bezier(0.4, 0.4, 0.0, 1)","fill":"both"}] Rodrigo Pereira/Pexels

[{"selector":"#anim-59db34a7-6cd7-4c66-85da-953c17da2ac4","keyframes":{"opacity":[0,1]},"delay":0,"duration":1500,"easing":"cubic-bezier(0.4, 0.4, 0.0, 1)","fill":"both"}] [{"selector":"#anim-5e2d1ae0-62d8-4e72-9ea0-daf3761c67b4","keyframes":{"opacity":[0,1]},"delay":0,"duration":600,"easing":"cubic-bezier(0.4, 0.4, 0.0, 1)","fill":"both"}] [{"selector":"#anim-a0ad2c52-54e2-46e6-926a-40481612f797","keyframes":{"opacity":[0,1]},"delay":0,"duration":500,"easing":"cubic-bezier(.3,0,.55,1)","fill":"both"}] [{"selector":"#anim-2f0197e4-7531-433f-a2c0-bbe1fb0d8814","keyframes":{"transform":["scale(0.3333333333333333)","scale(1)"]},"delay":0,"duration":500,"easing":"cubic-bezier(.3,0,.55,1)","fill":"forwards"}] [{"selector":"#anim-c28f343d-168b-46b2-a2bf-de823a884596 [data-leaf-element=\"true\"]","keyframes":{"transform":["translate3d(31.25267845767055%, 0, 0)","translate3d(0%, 0, 0)"]},"delay":0,"duration":2000,"easing":"cubic-bezier(.3,0,.55,1)","fill":"both"}] Uma nova molécula chamada MCH11 foi descoberta por pesquisadores e mostrou ser capaz de reduzir o consumo de álcool e a vontade de beber em camundongos Joshua J. Cotten/Unsplash

[{"selector":"#anim-cb1ba0c4-4a7a-4ff1-9ef7-239e6ba5a769","keyframes":{"opacity":[0,1]},"delay":0,"duration":1500,"easing":"cubic-bezier(0.4, 0.4, 0.0, 1)","fill":"both"}] [{"selector":"#anim-a0217608-d365-48f1-84b0-dc41157aeae6","keyframes":{"opacity":[0,1]},"delay":0,"duration":600,"easing":"cubic-bezier(0.4, 0.4, 0.0, 1)","fill":"both"}] [{"selector":"#anim-10207d3f-44f1-488d-af49-7e518714f749","keyframes":{"opacity":[0,1]},"delay":0,"duration":500,"easing":"cubic-bezier(.3,0,.55,1)","fill":"both"}] [{"selector":"#anim-69d1f737-6d2b-4d15-a160-f25093d081a7","keyframes":{"transform":["scale(0.3333333333333333)","scale(1)"]},"delay":0,"duration":500,"easing":"cubic-bezier(.3,0,.55,1)","fill":"forwards"}] [{"selector":"#anim-f95e1433-0fcf-4ca0-b045-1e736b6928b8 [data-leaf-element=\"true\"]","keyframes":{"transform":["translate3d(-23.25613823333145%, 0, 0)","translate3d(0%, 0, 0)"]},"delay":0,"duration":2000,"easing":"cubic-bezier(.3,0,.55,1)","fill":"both"}] Embora ainda não esteja disponível para uso humano, o componente pode abrir caminho para tratamentos personalizados para o alcoolismo Engin Akyurt/Pexels

[{"selector":"#anim-f435a8dd-270a-435d-890f-a7230e5e1548","keyframes":{"opacity":[0,1]},"delay":0,"duration":1500,"easing":"cubic-bezier(0.4, 0.4, 0.0, 1)","fill":"both"}] [{"selector":"#anim-6cd66063-97e2-4bf9-b135-50e895b79be7","keyframes":{"opacity":[0,1]},"delay":0,"duration":600,"easing":"cubic-bezier(0.4, 0.4, 0.0, 1)","fill":"both"}] [{"selector":"#anim-1d0b3d01-a65e-49ef-941d-21b66bec6b00","keyframes":{"opacity":[0,1]},"delay":0,"duration":500,"easing":"cubic-bezier(.3,0,.55,1)","fill":"both"}] [{"selector":"#anim-21a4f46c-a4d8-4d32-9f70-90ba37935807","keyframes":{"transform":["scale(0.3333333333333333)","scale(1)"]},"delay":0,"duration":500,"easing":"cubic-bezier(.3,0,.55,1)","fill":"forwards"}] [{"selector":"#anim-eee77067-e90a-4b29-a61f-7a103a832cb4 [data-leaf-element=\"true\"]","keyframes":{"transform":["translate3d(0, 40.11463251375983%, 0)","translate3d(0, 0%, 0)"]},"delay":0,"duration":2000,"easing":"cubic-bezier(.3,0,.55,1)","fill":"both"}] A descoberta é fruto do trabalho de uma equipe do Instituto de Neurociências (um centro conjunto UMH-CSIC), do Instituto de Saúde e Pesquisa Biomédica de Alicante (ISABIAL) e da Rede de Pesquisa em Dependência Química na Atenção Primária (RIAPAD) cottonbro studio/Pexels

[{"selector":"#anim-19bfa5e6-50e4-4c86-b6d9-68ea79c5bac4","keyframes":{"opacity":[0,1]},"delay":0,"duration":1500,"easing":"cubic-bezier(0.4, 0.4, 0.0, 1)","fill":"both"}] [{"selector":"#anim-b5573c90-aec4-419c-aa66-1f61c857c2f3","keyframes":{"opacity":[0,1]},"delay":0,"duration":600,"easing":"cubic-bezier(0.4, 0.4, 0.0, 1)","fill":"both"}] [{"selector":"#anim-98536841-9789-4cc0-9ff0-eb4bf2ae72da","keyframes":{"opacity":[0,1]},"delay":0,"duration":500,"easing":"cubic-bezier(.3,0,.55,1)","fill":"both"}] [{"selector":"#anim-629cf806-4043-4498-ad48-42568929fea6","keyframes":{"transform":["scale(0.3333333333333333)","scale(1)"]},"delay":0,"duration":500,"easing":"cubic-bezier(.3,0,.55,1)","fill":"forwards"}] [{"selector":"#anim-1fc44a3f-e178-4c45-8350-f3ea06f76e2e [data-leaf-element=\"true\"]","keyframes":{"transform":["translate3d(0, 37.4481829229264%, 0)","translate3d(0, 0%, 0)"]},"delay":0,"duration":2000,"easing":"cubic-bezier(.3,0,.55,1)","fill":"both"}] Segundo o pesquisador Abraham Torregrosa, primeiro autor do estudo, as terapias atuais para o transtorno por uso de álcool possuem "sérias limitações". Ele explica que até 70% dos pacientes recaem no consumo de álcool no primeiro ano de tratamento Pavel Danilyuk/Pexels

[{"selector":"#anim-55cc91fc-2c80-45c3-a5d5-e376b1be5d71","keyframes":{"opacity":[0,1]},"delay":0,"duration":1500,"easing":"cubic-bezier(0.4, 0.4, 0.0, 1)","fill":"both"}] [{"selector":"#anim-e4aec096-c725-45bd-9580-c7bd4cf9b336","keyframes":{"opacity":[0,1]},"delay":0,"duration":600,"easing":"cubic-bezier(0.4, 0.4, 0.0, 1)","fill":"both"}] [{"selector":"#anim-d31375bf-bc25-433d-aeeb-7fed6a1fd4ca","keyframes":{"opacity":[0,1]},"delay":0,"duration":500,"easing":"cubic-bezier(.3,0,.55,1)","fill":"both"}] [{"selector":"#anim-b0cdd6e2-af7a-4b88-a41b-66a306909947","keyframes":{"transform":["scale(0.3333333333333333)","scale(1)"]},"delay":0,"duration":500,"easing":"cubic-bezier(.3,0,.55,1)","fill":"forwards"}] [{"selector":"#anim-57c4371c-12ba-45a0-ba1e-0b1910f066ea [data-leaf-element=\"true\"]","keyframes":{"transform":["translate3d(11.495535485703195%, 0, 0)","translate3d(0%, 0, 0)"]},"delay":0,"duration":2000,"easing":"cubic-bezier(.3,0,.55,1)","fill":"both"}] Para buscar a melhor forma de tratar a doença, os pesquisadores se concentram no sistema endocanabinoide , uma rede de sinalização que liga o sistema nervoso ao resto do organismo e está envolvida na regulação do prazer, da motivação e do estresse Freepick

[{"selector":"#anim-c814fb4b-b187-4d2f-a4c2-951cfb6843e7","keyframes":{"opacity":[0,1]},"delay":0,"duration":1500,"easing":"cubic-bezier(0.4, 0.4, 0.0, 1)","fill":"both"}] [{"selector":"#anim-49d3f1ea-ee32-482d-9a14-837af6faa33c","keyframes":{"opacity":[0,1]},"delay":0,"duration":600,"easing":"cubic-bezier(0.4, 0.4, 0.0, 1)","fill":"both"}] [{"selector":"#anim-09d5e71c-68f5-474d-b4c6-a00b53a5cdfa","keyframes":{"opacity":[0,1]},"delay":0,"duration":500,"easing":"cubic-bezier(.3,0,.55,1)","fill":"both"}] [{"selector":"#anim-12654afe-aad8-4b8c-b195-cd24fd301736","keyframes":{"transform":["scale(0.3333333333333333)","scale(1)"]},"delay":0,"duration":500,"easing":"cubic-bezier(.3,0,.55,1)","fill":"forwards"}] [{"selector":"#anim-8ad53a97-0024-458b-a906-d9ba433d18e6 [data-leaf-element=\"true\"]","keyframes":{"transform":["translate3d(-7.80868980087992%, 0, 0)","translate3d(0%, 0, 0)"]},"delay":0,"duration":2000,"easing":"cubic-bezier(.3,0,.55,1)","fill":"both"}] Em pessoas com transtorno por uso de álcool, esse sistema fica desequilibrado, reduzindo os níveis de moléculas como o 2-araquidonoilglicerol (2-AG), que está relacionado ao bem-estar e ao controle dos impulsos cottonbro studio/pexels

[{"selector":"#anim-b419630c-7f27-44c6-83b3-dd9804c952b5","keyframes":{"opacity":[0,1]},"delay":0,"duration":1500,"easing":"cubic-bezier(0.4, 0.4, 0.0, 1)","fill":"both"}] [{"selector":"#anim-05ffbf76-066d-40fc-a622-e6117075d11c","keyframes":{"opacity":[0,1]},"delay":0,"duration":600,"easing":"cubic-bezier(0.4, 0.4, 0.0, 1)","fill":"both"}] [{"selector":"#anim-6886cbe3-cb7d-427d-a000-64a85ac32a85","keyframes":{"opacity":[0,1]},"delay":0,"duration":500,"easing":"cubic-bezier(.3,0,.55,1)","fill":"both"}] [{"selector":"#anim-c941adf1-5dc5-4c1c-9c8a-31760fbeec38","keyframes":{"transform":["scale(0.3333333333333333)","scale(1)"]},"delay":0,"duration":500,"easing":"cubic-bezier(.3,0,.55,1)","fill":"forwards"}] [{"selector":"#anim-57196538-4f15-4eb6-8caa-64b0535b655a [data-leaf-element=\"true\"]","keyframes":{"transform":["translate3d(7.806472097164625%, 0, 0)","translate3d(0%, 0, 0)"]},"delay":0,"duration":2000,"easing":"cubic-bezier(.3,0,.55,1)","fill":"both"}] A molécula MCH11 atua como inibidora da monoacilglicerol lipase, uma enzima que degrada o 2-AG. Ao bloquear essa enzima, a quantidade de 2-AG disponível no cérebro aumenta, reduzindo tanto a necessidade de beber quanto os sintomas de abstinência cottonbro studio/Pexels

[{"selector":"#anim-9ed36e0d-a334-494e-bb7f-d3a025fb6c27","keyframes":{"opacity":[0,1]},"delay":0,"duration":1500,"easing":"cubic-bezier(0.4, 0.4, 0.0, 1)","fill":"both"}] [{"selector":"#anim-272164a3-c67d-4941-a95f-00d0e7745d17","keyframes":{"opacity":[0,1]},"delay":0,"duration":600,"easing":"cubic-bezier(0.4, 0.4, 0.0, 1)","fill":"both"}] [{"selector":"#anim-a4f014cd-94f4-45b4-b090-72d92fd870ff","keyframes":{"opacity":[0,1]},"delay":0,"duration":500,"easing":"cubic-bezier(.3,0,.55,1)","fill":"both"}] [{"selector":"#anim-f7abfdf4-a23a-4821-8a19-4cb255af6ed4","keyframes":{"transform":["scale(0.3333333333333333)","scale(1)"]},"delay":0,"duration":500,"easing":"cubic-bezier(.3,0,.55,1)","fill":"forwards"}] Segundo os pesquisadores, o tratamento com MCH11 em camundongos se mostrou eficaz e seletivo, demonstrando benefícios contra a ansiedade e a depressão sem prejudicar funções motoras ou cognitivas Kanashi/Unsplash

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