Cientistas do Brasil e Índia criam tratamento para tumores sólidos

Cientistas do Brasil e da Índia criam tratamento para tumores sólidos

[{"selector":"#anim-8e0ca48d-2548-4333-bf42-5771726343f5","keyframes":{"opacity":[0,1]},"delay":0,"duration":1000,"easing":"cubic-bezier(0.4, 0.4, 0.0, 1)","fill":"both"}] [{"selector":"#anim-9f760930-1ab3-4fdb-bc38-30d0e4abee0a","keyframes":{"opacity":[0,1]},"delay":0,"duration":500,"easing":"cubic-bezier(.3,0,.55,1)","fill":"both"}] [{"selector":"#anim-70a58f2c-a642-4b4f-933f-f8c23468a495","keyframes":{"transform":["scale(0.3333333333333333)","scale(1)"]},"delay":0,"duration":500,"easing":"cubic-bezier(.3,0,.55,1)","fill":"forwards"}] [{"selector":"#anim-f37d218c-c078-49d2-a78c-76363e43d8dc","keyframes":{"opacity":[0,1]},"delay":0,"duration":600,"easing":"cubic-bezier(0.4, 0.4, 0.0, 1)","fill":"both"}] UNSPLASH

[{"selector":"#anim-30a609b8-91aa-406c-bd49-69cae3f442ff","keyframes":{"opacity":[0,1]},"delay":0,"duration":1500,"easing":"cubic-bezier(0.4, 0.4, 0.0, 1)","fill":"both"}] [{"selector":"#anim-8aefc4b5-1b46-43df-ac80-c2a643661bdf","keyframes":{"opacity":[0,1]},"delay":0,"duration":600,"easing":"cubic-bezier(0.4, 0.4, 0.0, 1)","fill":"both"}] [{"selector":"#anim-c53f4b23-4691-4d00-8117-b5611beb5d21","keyframes":{"opacity":[0,1]},"delay":0,"duration":500,"easing":"cubic-bezier(.3,0,.55,1)","fill":"both"}] [{"selector":"#anim-766bae50-22e1-448b-abbf-284e4054600a","keyframes":{"transform":["scale(0.3333333333333333)","scale(1)"]},"delay":0,"duration":500,"easing":"cubic-bezier(.3,0,.55,1)","fill":"forwards"}] Artigo no Journal of Controlled Release detalha resultado de colaboração que desenvolveu alternativa para tratar tumores sólidos por inibição do microambiente tumoral inflamatório UNSPLASH

[{"selector":"#anim-bd941d02-5eec-411b-b00f-56d085e90689","keyframes":{"opacity":[0,1]},"delay":0,"duration":1500,"easing":"cubic-bezier(0.4, 0.4, 0.0, 1)","fill":"both"}] [{"selector":"#anim-45d3b7c0-8836-4f07-86a8-72243db210ba","keyframes":{"opacity":[0,1]},"delay":0,"duration":600,"easing":"cubic-bezier(0.4, 0.4, 0.0, 1)","fill":"both"}] [{"selector":"#anim-47b823ff-5634-4d16-91dd-36e9b53a82da","keyframes":{"opacity":[0,1]},"delay":0,"duration":500,"easing":"cubic-bezier(.3,0,.55,1)","fill":"both"}] [{"selector":"#anim-226cb3a2-2c44-4e6b-a9c0-ad7bfdb1a13e","keyframes":{"transform":["scale(0.3333333333333333)","scale(1)"]},"delay":0,"duration":500,"easing":"cubic-bezier(.3,0,.55,1)","fill":"forwards"}] Tumores sólidos costumam ser os tipos de câncer de tratamento mais desafiador por causa da dificuldade de penetração dos fármacos UNSPLASH

[{"selector":"#anim-bb66d6e6-a5ec-43d7-b057-7d66975065b0","keyframes":{"opacity":[0,1]},"delay":0,"duration":1500,"easing":"cubic-bezier(0.4, 0.4, 0.0, 1)","fill":"both"}] [{"selector":"#anim-e37a9cac-9164-4392-86fa-0b9a9047c4a6","keyframes":{"opacity":[0,1]},"delay":0,"duration":600,"easing":"cubic-bezier(0.4, 0.4, 0.0, 1)","fill":"both"}] [{"selector":"#anim-a3ad9bee-83fc-47cd-8fe4-cf19c2ac937c","keyframes":{"opacity":[0,1]},"delay":0,"duration":500,"easing":"cubic-bezier(.3,0,.55,1)","fill":"both"}] [{"selector":"#anim-03b7bc19-d005-48c0-8280-0d0830303435","keyframes":{"transform":["scale(0.3333333333333333)","scale(1)"]},"delay":0,"duration":500,"easing":"cubic-bezier(.3,0,.55,1)","fill":"forwards"}] O microambiente tumoral inflamatório, onde tumores estão alojados, contém células e substâncias que impedem as células de defesa de combater o tumor UNSPLASH

[{"selector":"#anim-f5abb9b7-525e-4a73-a29f-8f27a150d3f0","keyframes":{"opacity":[0,1]},"delay":0,"duration":600,"easing":"cubic-bezier(0.2, 0.6, 0.0, 1)","fill":"both"}] [{"selector":"#anim-424d6b09-12f0-4e44-b2e6-6cac39b98840","keyframes":{"transform":["translate3d(0px, 195.92594%, 0)","translate3d(0px, 0px, 0)"]},"delay":0,"duration":600,"easing":"cubic-bezier(0.2, 0.6, 0.0, 1)","fill":"both"}] [{"selector":"#anim-6c61e148-18ad-425e-9cb4-c12b751071ef","keyframes":{"opacity":[0,1]},"delay":0,"duration":600,"easing":"cubic-bezier(0.2, 0.6, 0.0, 1)","fill":"both"}] [{"selector":"#anim-84ec7b19-1a57-4095-946e-c559683c618e","keyframes":{"transform":["translate3d(0px, 715.34346%, 0)","translate3d(0px, 0px, 0)"]},"delay":0,"duration":600,"easing":"cubic-bezier(0.2, 0.6, 0.0, 1)","fill":"both"}] Há sempre um cabo de guerra entre células imunológicas promotoras e inibidoras de tumores no TME, onde metabólitos, mediadores lipídicos, citocinas e quimiocinas desempenham um papel importante no domínio da natureza imunossupressora Autores do estudo

[{"selector":"#anim-c39af0b6-0234-475e-a062-ebf12096c725","keyframes":{"opacity":[0,1]},"delay":0,"duration":1500,"easing":"cubic-bezier(0.4, 0.4, 0.0, 1)","fill":"both"}] [{"selector":"#anim-556edd5d-d3bc-41b7-adf3-ab398c6d2c56","keyframes":{"opacity":[0,1]},"delay":0,"duration":600,"easing":"cubic-bezier(0.4, 0.4, 0.0, 1)","fill":"both"}] [{"selector":"#anim-b74942ac-bf82-475e-b9fe-31a8bec5d546","keyframes":{"opacity":[0,1]},"delay":0,"duration":500,"easing":"cubic-bezier(.3,0,.55,1)","fill":"both"}] [{"selector":"#anim-e822fe25-4cff-4a3c-83f5-fb0d71972f5e","keyframes":{"transform":["scale(0.3333333333333333)","scale(1)"]},"delay":0,"duration":500,"easing":"cubic-bezier(.3,0,.55,1)","fill":"forwards"}] A equipe desenvolveu partículas compostas de diferentes substâncias usadas para matar as células tumorais e diminuir a produção de várias substâncias inflamatórias UNSPLASH

[{"selector":"#anim-a2dcbfe2-454e-45bd-bc71-1e1e133ad90a","keyframes":{"opacity":[0,1]},"delay":0,"duration":1500,"easing":"cubic-bezier(0.4, 0.4, 0.0, 1)","fill":"both"}] [{"selector":"#anim-323d4871-962c-4d83-a3e0-d951fd0fd8ef","keyframes":{"opacity":[0,1]},"delay":0,"duration":600,"easing":"cubic-bezier(0.4, 0.4, 0.0, 1)","fill":"both"}] [{"selector":"#anim-0a0dafc2-2d8f-465f-8df4-14373defcaae","keyframes":{"opacity":[0,1]},"delay":0,"duration":500,"easing":"cubic-bezier(.3,0,.55,1)","fill":"both"}] [{"selector":"#anim-5662fc7d-f920-4988-86f3-5efc4e3743ef","keyframes":{"transform":["scale(0.3333333333333333)","scale(1)"]},"delay":0,"duration":500,"easing":"cubic-bezier(.3,0,.55,1)","fill":"forwards"}] Os estudos em animais de laboratório mostraram que essas partículas, ministradas por via intravenosa, foram muito eficientes, diminuindo o tamanho de tumores e aumentando a sobrevida dos animais UNSPLASH

CNNBRASIL.COM.BR

[{"selector":"#anim-17f1c410-95ae-474b-92de-0796ed643d66","keyframes":{"opacity":[0,1]},"delay":0,"duration":600,"easing":"cubic-bezier(0.4, 0.4, 0.0, 1)","fill":"both"}] [{"selector":"#anim-800c5507-b2ab-4287-9bb3-aafdab4365ea","keyframes":{"opacity":[0,1]},"delay":0,"duration":600,"easing":"cubic-bezier(0.4, 0.4, 0.0, 1)","fill":"both"}] [{"selector":"#anim-5683c1eb-b3d2-4b82-bf01-944f617ce14f","keyframes":{"opacity":[0,1]},"delay":0,"duration":1000,"easing":"cubic-bezier(0.2, 0.6, 0.0, 1)","fill":"both"}] [{"selector":"#anim-623dc892-8cb9-413d-a553-8ba47d2aa981","keyframes":{"transform":["translate3d(0px, 2051.01057%, 0)","translate3d(0px, 0px, 0)"]},"delay":0,"duration":1000,"easing":"cubic-bezier(0.2, 0.6, 0.0, 1)","fill":"both"}] [{"selector":"#anim-c21677f3-f588-445c-a459-ef761a68ea4e","keyframes":{"opacity":[0,1]},"delay":0,"duration":600,"easing":"cubic-bezier(0.2, 0.6, 0.0, 1)","fill":"both"}] [{"selector":"#anim-0095e819-f437-4787-8656-0d9a32929ef6","keyframes":{"transform":["translate3d(-117.10037%, 0px, 0)","translate3d(0px, 0px, 0)"]},"delay":0,"duration":600,"easing":"cubic-bezier(0.2, 0.6, 0.0, 1)","fill":"both"}] [{"selector":"#anim-badd7206-7c96-43ee-8495-c7729cf796e7","keyframes":{"opacity":[0,1]},"delay":0,"duration":1000,"easing":"cubic-bezier(0.2, 0.6, 0.0, 1)","fill":"both"}] [{"selector":"#anim-05832425-f849-4c15-b766-775d3c30e378","keyframes":{"transform":["translate3d(0px, 1157.35637%, 0)","translate3d(0px, 0px, 0)"]},"delay":0,"duration":1000,"easing":"cubic-bezier(0.2, 0.6, 0.0, 1)","fill":"both"}] VEJA MAIS EM UNSPLASH Arraste para cima