Cientistas veem Mounjaro reduzir obsessão por comida no cérebro

Cientistas veem Mounjaro reduzir obsessão por comida diretamente no cérebro

[{"selector":"#anim-0282da6f-0041-4112-a5e5-2d336a1dde5a","keyframes":{"opacity":[0,1]},"delay":0,"duration":1000,"easing":"cubic-bezier(0.4, 0.4, 0.0, 1)","fill":"both"}] [{"selector":"#anim-a57b5d8d-ee08-4116-9d55-840e23529480","keyframes":{"opacity":[0,1]},"delay":0,"duration":500,"easing":"cubic-bezier(.3,0,.55,1)","fill":"both"}] [{"selector":"#anim-699404e0-a227-49d3-8923-2dbef2b8de41","keyframes":{"transform":["scale(0.3333333333333333)","scale(1)"]},"delay":0,"duration":500,"easing":"cubic-bezier(.3,0,.55,1)","fill":"forwards"}] [{"selector":"#anim-4222f5f8-f64d-4702-a17b-1b1a2b6a128d","keyframes":{"opacity":[0,1]},"delay":0,"duration":600,"easing":"cubic-bezier(0.4, 0.4, 0.0, 1)","fill":"both"}] Getty Images

[{"selector":"#anim-c549d91b-c09e-46c5-a535-d4b001438245","keyframes":{"opacity":[0,1]},"delay":0,"duration":1500,"easing":"cubic-bezier(0.4, 0.4, 0.0, 1)","fill":"both"}] [{"selector":"#anim-ae929a35-34f9-4972-a2fa-c234b946da5d","keyframes":{"opacity":[0,1]},"delay":0,"duration":500,"easing":"cubic-bezier(.3,0,.55,1)","fill":"both"}] [{"selector":"#anim-0264a528-c28a-4308-8a9a-23d6ed40f3ee","keyframes":{"transform":["scale(0.3333333333333333)","scale(1)"]},"delay":0,"duration":500,"easing":"cubic-bezier(.3,0,.55,1)","fill":"forwards"}] [{"selector":"#anim-e88ddeda-008b-4b5b-bfde-635d5d5f28d2","keyframes":{"opacity":[0,1]},"delay":0,"duration":600,"easing":"cubic-bezier(0.4, 0.4, 0.0, 1)","fill":"both"}] [{"selector":"#anim-e71e8558-45e6-4d44-b0f4-20a386abec3b [data-leaf-element=\"true\"]","keyframes":{"transform":["translate3d(29.31818079603699%, 0, 0)","translate3d(0%, 0, 0)"]},"delay":0,"duration":2000,"easing":"cubic-bezier(.3,0,.55,1)","fill":"both"}] Pesquisadores da Universidade da Pensilvânia (EUA) identificaram o primeiro registro cerebral direto do efeito da tirzepatida, o princípio ativo do Mounjaro, no núcleo accumbens Pixabay/Pexels

[{"selector":"#anim-0e369519-fa36-4b43-999a-88f4608126c4","keyframes":{"opacity":[0,1]},"delay":0,"duration":1500,"easing":"cubic-bezier(0.4, 0.4, 0.0, 1)","fill":"both"}] [{"selector":"#anim-d747a86b-6779-435f-a23f-f5abfad7aaa7","keyframes":{"opacity":[0,1]},"delay":0,"duration":500,"easing":"cubic-bezier(.3,0,.55,1)","fill":"both"}] [{"selector":"#anim-181a468b-9ce8-4769-bbc7-9ccbf6341777","keyframes":{"transform":["scale(0.3333333333333333)","scale(1)"]},"delay":0,"duration":500,"easing":"cubic-bezier(.3,0,.55,1)","fill":"forwards"}] [{"selector":"#anim-1f84a26c-5f5c-454f-a057-d2162c89b6f1","keyframes":{"opacity":[0,1]},"delay":0,"duration":600,"easing":"cubic-bezier(0.4, 0.4, 0.0, 1)","fill":"both"}] [{"selector":"#anim-5e2cb817-e6ea-4a73-a772-5824c6f0d704 [data-leaf-element=\"true\"]","keyframes":{"transform":["translate3d(-0.0676084249587089%, 0, 0)","translate3d(0%, 0, 0)"]},"delay":0,"duration":2000,"easing":"cubic-bezier(.3,0,.55,1)","fill":"both"}] É a primeira vez que cientistas conseguem observar em tempo real e diretamente no circuito de recompensa do cérebro, um medicamento para obesidade agindo sobre neurônios reais Anna Shvets/Pexels

[{"selector":"#anim-1b09774b-16d8-463b-a268-e01269b00707","keyframes":{"opacity":[0,1]},"delay":0,"duration":1500,"easing":"cubic-bezier(0.4, 0.4, 0.0, 1)","fill":"both"}] [{"selector":"#anim-9684d003-f68d-43da-a18d-c653a72b8da8","keyframes":{"opacity":[0,1]},"delay":0,"duration":500,"easing":"cubic-bezier(.3,0,.55,1)","fill":"both"}] [{"selector":"#anim-b4822143-78ca-4927-903b-81abb16c234b","keyframes":{"transform":["scale(0.3333333333333333)","scale(1)"]},"delay":0,"duration":500,"easing":"cubic-bezier(.3,0,.55,1)","fill":"forwards"}] [{"selector":"#anim-12c029e1-c8e8-424d-9d02-98742ef04037","keyframes":{"opacity":[0,1]},"delay":0,"duration":600,"easing":"cubic-bezier(0.4, 0.4, 0.0, 1)","fill":"both"}] [{"selector":"#anim-75c75f95-193b-4a11-87fb-812096bdd27e [data-leaf-element=\"true\"]","keyframes":{"transform":["translate3d(8.599015360242584%, 0, 0)","translate3d(0%, 0, 0)"]},"delay":0,"duration":2000,"easing":"cubic-bezier(.3,0,.55,1)","fill":"both"}] O estudo publicado na Nature Medicine, foi direcionado a pacientes que, após tentarem dietas, exercícios, medicamentos para perda de peso, terapias e até cirurgia bariátrica, continuaram com compulsão alimentar Chokniti Khongchum/Pexels

[{"selector":"#anim-598e1c11-145b-47f8-bc37-fa2a08e6a026","keyframes":{"opacity":[0,1]},"delay":0,"duration":1500,"easing":"cubic-bezier(0.4, 0.4, 0.0, 1)","fill":"both"}] [{"selector":"#anim-bac7b6b5-7e48-4f7b-bcf4-8ee0be2f295d","keyframes":{"opacity":[0,1]},"delay":0,"duration":500,"easing":"cubic-bezier(.3,0,.55,1)","fill":"both"}] [{"selector":"#anim-9a99bacc-1265-4236-9a03-be06a16686ca","keyframes":{"transform":["scale(0.3333333333333333)","scale(1)"]},"delay":0,"duration":500,"easing":"cubic-bezier(.3,0,.55,1)","fill":"forwards"}] [{"selector":"#anim-45977df0-4cef-44cd-9316-0f6e8bf03237","keyframes":{"opacity":[0,1]},"delay":0,"duration":600,"easing":"cubic-bezier(0.4, 0.4, 0.0, 1)","fill":"both"}] [{"selector":"#anim-35c054af-b3e9-4a30-9d7c-a02002a19424 [data-leaf-element=\"true\"]","keyframes":{"transform":["translate3d(0, -16.97954699813789%, 0)","translate3d(0, 0%, 0)"]},"delay":0,"duration":2000,"easing":"cubic-bezier(.3,0,.55,1)","fill":"both"}] O experimento também mostrou que o Mounjaro consegue agir diretamente em um centro de recompensa do cérebro, e reduzir os sinais que provocam a vontade intensa de comer Edward Jenner/Pexels

[{"selector":"#anim-95a4b6c8-3604-45ce-9d33-5036a4dc4aa0","keyframes":{"opacity":[0,1]},"delay":0,"duration":1500,"easing":"cubic-bezier(0.4, 0.4, 0.0, 1)","fill":"both"}] [{"selector":"#anim-e15736f9-d97c-4d0b-aafb-6d93ae4c9eef","keyframes":{"opacity":[0,1]},"delay":0,"duration":500,"easing":"cubic-bezier(.3,0,.55,1)","fill":"both"}] [{"selector":"#anim-13bc86c1-63fe-4c29-ba54-48a3de315415","keyframes":{"transform":["scale(0.3333333333333333)","scale(1)"]},"delay":0,"duration":500,"easing":"cubic-bezier(.3,0,.55,1)","fill":"forwards"}] [{"selector":"#anim-2fb31e0e-849c-4b6b-b27b-926770f32d8a","keyframes":{"opacity":[0,1]},"delay":0,"duration":600,"easing":"cubic-bezier(0.4, 0.4, 0.0, 1)","fill":"both"}] Nesse sentido, a tirzepatida parece acalmar um padrão de atividade cerebral disfuncional que está por trás do impulso intenso de buscar comida Tara Winstead/Pexels

[{"selector":"#anim-f533143a-64b4-473a-a502-3a8b7e7818f0","keyframes":{"opacity":[0,1]},"delay":0,"duration":1500,"easing":"cubic-bezier(0.4, 0.4, 0.0, 1)","fill":"both"}] [{"selector":"#anim-87fd71cf-87ec-4d59-9a42-9a0e17cc7df3","keyframes":{"opacity":[0,1]},"delay":0,"duration":500,"easing":"cubic-bezier(.3,0,.55,1)","fill":"both"}] [{"selector":"#anim-1e291f3b-bc9e-44e0-bb98-808747b21ead","keyframes":{"transform":["scale(0.3333333333333333)","scale(1)"]},"delay":0,"duration":500,"easing":"cubic-bezier(.3,0,.55,1)","fill":"forwards"}] [{"selector":"#anim-ecafcee8-3958-470a-93d8-1e6336bbe0cf","keyframes":{"opacity":[0,1]},"delay":0,"duration":600,"easing":"cubic-bezier(0.4, 0.4, 0.0, 1)","fill":"both"}] [{"selector":"#anim-7b566808-8b6a-4525-b7f9-3c00b1fad06b [data-leaf-element=\"true\"]","keyframes":{"transform":["translate3d(44.29760765344227%, 0, 0)","translate3d(0%, 0, 0)"]},"delay":0,"duration":2000,"easing":"cubic-bezier(.3,0,.55,1)","fill":"both"}] Isso significa que o medicamento não atua só no apetite, mas também no circuito cerebral que controla motivação, prazer e vontade de comer Nathan Cowley/Pexels

CNNBRASIL.COM.BR

[{"selector":"#anim-23757016-5c8a-4f11-a12d-3e07230c611b","keyframes":{"opacity":[0,1]},"delay":0,"duration":600,"easing":"cubic-bezier(0.4, 0.4, 0.0, 1)","fill":"both"}] [{"selector":"#anim-e097d5a4-9755-4e68-87ea-53722106df01","keyframes":{"opacity":[0,1]},"delay":0,"duration":600,"easing":"cubic-bezier(0.4, 0.4, 0.0, 1)","fill":"both"}] [{"selector":"#anim-74d4c9a7-4fee-492a-b64a-1dbc315991ae","keyframes":{"opacity":[0,1]},"delay":0,"duration":1000,"easing":"cubic-bezier(0.2, 0.6, 0.0, 1)","fill":"both"}] [{"selector":"#anim-1dc09fe0-872a-4cba-84ca-7a96ac4008ef","keyframes":{"transform":["translate3d(0px, 2132.63615%, 0)","translate3d(0px, 0px, 0)"]},"delay":0,"duration":1000,"easing":"cubic-bezier(0.2, 0.6, 0.0, 1)","fill":"both"}] [{"selector":"#anim-6a747c95-d991-44c2-bfac-2dfd8f051874","keyframes":{"opacity":[0,1]},"delay":0,"duration":600,"easing":"cubic-bezier(0.2, 0.6, 0.0, 1)","fill":"both"}] [{"selector":"#anim-8614efa9-6403-4960-a8fd-f0f821db40bd","keyframes":{"transform":["translate3d(-117.84387%, 0px, 0)","translate3d(0px, 0px, 0)"]},"delay":0,"duration":600,"easing":"cubic-bezier(0.2, 0.6, 0.0, 1)","fill":"both"}] [{"selector":"#anim-99f39b18-988a-4662-9b59-5f4c52ad2765","keyframes":{"opacity":[0,1]},"delay":0,"duration":1000,"easing":"cubic-bezier(0.2, 0.6, 0.0, 1)","fill":"both"}] [{"selector":"#anim-2b8df6ea-b4b8-41fe-8471-4803cfde73f7","keyframes":{"transform":["translate3d(0px, 1223.93157%, 0)","translate3d(0px, 0px, 0)"]},"delay":0,"duration":1000,"easing":"cubic-bezier(0.2, 0.6, 0.0, 1)","fill":"both"}] leia mais em Getty Images